南方科技大学知识苑(SUSTech KC): 手性分子ee值测量方法

Title	手性分子ee值测量方法
Alternative Title	Chiral molecule ee value measuring method
Author	蒋伟; 王力立
First Inventor	蒋伟
Original applicant	南方科技大学
First applicant	南方科技大学
Address of First applicant	518000 广东省深圳市南山区学苑大道1088号
Current applicant	南方科技大学
Address of Current applicant	518000 广东省深圳市南山区学苑大道1088号 (广东,深圳,南山区)
First Current Applicant	南方科技大学
Address of First Current Applicant	518000 广东省深圳市南山区学苑大道1088号 (广东,深圳,南山区)
Application Number	CN202010278361.8
Application Date	2020-04-09
Open (Notice) Number	CN111398181A
Date Available	2020-07-10
Status of Patent	驳回
Legal Date	2022-12-23
Subtype	发明申请
SUSTech Authorship	First
Abstract	本发明公开了一种手性分子ee值测量方法，通过配制含有预设主体分子的主体溶液；在所述主体溶液中加入饱和浓度的待测量手性分子的客体溶液，得到CD信号饱和的待检测溶液；测定所述待检测溶液在CD光谱预设位置的第一CD信号强度值，将所述第一CD信号强度值代入预设标准曲线方程，以计算所述待测量手性分子的ee值。相比于传统的色谱法，本发明利用CD光谱来测量ee值的方式所需检测溶剂更少，减少了检测成本，且能够更加快速、简便检测出手性分子的ee值，得以适用于高通量的不对称催化反应条件的筛选和催化反应的实时监控。
Other Abstract	The invention discloses a chiral molecule ee value measuring method. The method comprises the following steps: preparing a main body solution containing a preset main body molecule; adding an object solution of chiral molecules to be measured with saturated concentration into the main body solution to obtain a solution to be detected with saturated CD signals; and determining a first CD signal intensity value of the to-be-detected solution at a preset position of the CD spectrum, and substituting the first CD signal intensity value into a preset standard curve equation to calculate the ee value of the to-be-detected chiral molecule. Compared with a traditional chromatography method, the method measuring the ee value via the CD spectrum has the advantages that fewer detection solvents are needed, the detection cost is reduced, the ee value of the chiral molecule can be detected more quickly, simply and conveniently, and the method is suitable for screening of high-flux asymmetric catalytic reaction conditions and real-time monitoring of catalytic reaction.
CPC Classification Number	G01N21/19 ; G01N2201/129 ; G01N2201/122
IPC Classification Number	G01N21/19
INPADOC Legal Status	（-REJECTION OF INVENTION PATENT APPLICATION AFTER PUBLICATION）[2022-12-23][CN]
INPADOC Patent Family Count	2
Extended Patent Family Count	2
Priority date	2020-04-09
Patent Agent	张婷
Agency	深圳市世纪恒程知识产权代理事务所
URL	[Source Record]
Data Source	PatSnap
Document Type	Patent
Identifier	http://kc.sustech.edu.cn/handle/2SGJ60CL/532723
Department	Department of Chemistry 深圳格拉布斯研究院
Recommended Citation GB/T 7714	蒋伟,王力立. 手性分子ee值测量方法.

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