南方科技大学知识苑(SUSTech KC): 化合物dCTB在制备治疗癌性疼痛的药物中的应用

Title	化合物dCTB在制备治疗癌性疼痛的药物中的应用
Alternative Title	Use of compound dCTB in preparation of drugs for teatment of cancer pain
Author	宋学军
First Inventor	宋学军
Original applicant	南方科技大学
First applicant	南方科技大学
Address of First applicant	518000 广东省深圳市南山区西丽学苑大道1088号
Current applicant	南方科技大学
Address of Current applicant	518000 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)
First Current Applicant	南方科技大学
Address of First Current Applicant	518000 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)
Application Number	CN201811389651.9
Application Date	2018-11-21
Open (Notice) Number	CN109260200A
Date Available	2019-01-25
Status of Patent	实质审查
Legal Date	2019-02-26
Subtype	发明申请
SUSTech Authorship	First
Abstract	本发明涉及化合物dCTB在制备治疗癌性疼痛的药物中的应用，所述癌性疼痛包括由肿瘤压迫或肿瘤浸润导致的中重度疼痛。本发明首次揭示了化合物dCTB能够通过抑制脊髓背角的YAP和TAZ两种蛋白的表达和聚集来实现缓解癌性疼痛的功能，且在治疗过程中具有很强的针对性，疗效显著，副作用小，耐受性低，为研究癌性疼痛的治疗策略提供了理论依据，为制备新的治疗癌性疼痛的药物提供了一个嵌入点。
Other Abstract	The present invention relates to the use of the compound dCTB in the preparation of drugs for the treatment of cancerous pain, including moderate to severe pain caused by tumor compression or tumor infiltration. The invention discloses for the first time the compound dCTB can realize the function of relieving cancer pain by inhibiting the expression and aggregation of YAP and TAZ proteins in the spinal dorsal horn, and in the treatment process has a strong pertinence, significant efficacy, side effects, low tolerance, for the study of cancer pain treatment strategy provides a theoretical basisfor the preparation of new drugs to treat cancer pain to provide an insertion point.
CPC Classification Number	A61K31/433 ; A61P29/00 ; A61P35/00 ; C07D285/10
IPC Classification Number	A61K31/433 ; A61P29/00 ; A61P35/00 ; C07D285/10
INPADOC Legal Status	（ENTRY INTO FORCE OF REQUEST FOR SUBSTANTIVE EXAMINATION）[2019-02-26][CN]
INPADOC Patent Family Count	1
Extended Patent Family Count	1
Priority date	2018-11-21
Patent Agent	巩克栋
Agency	北京品源专利代理有限公司
URL	[Source Record]
Data Source	PatSnap
Document Type	Patent
Identifier	http://kc.sustech.edu.cn/handle/2SGJ60CL/532853
Department	Department of Medical Neuroscience
Recommended Citation GB/T 7714	宋学军. 化合物dCTB在制备治疗癌性疼痛的药物中的应用.

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