南方科技大学知识苑(SUSTech KC): 一种吲哚啉酮取代的环己二烯酮肟类化合物及其合成方法

Title	一种吲哚啉酮取代的环己二烯酮肟类化合物及其合成方法
Alternative Title	Indolinone substituted cyclohexadienone oxime compound and synthesis method thereof
Author	谭斌 ; 朱帅 ; 向少华
First Inventor	谭斌
Original applicant	南方科技大学
First applicant	南方科技大学
Address of First applicant	518055 广东省深圳市南山区桃源街道学苑大道1088号
Current applicant	南方科技大学
Address of Current applicant	518055 广东省深圳市南山区桃源街道学苑大道1088号 (广东,深圳,南山区)
First Current Applicant	南方科技大学
Address of First Current Applicant	518055 广东省深圳市南山区桃源街道学苑大道1088号 (广东,深圳,南山区)
Application Number	CN202210568329.2
Application Date	2022-05-18
Open (Notice) Number	CN114853660A
Date Available	2022-08-05
Status of Patent	实质审查
Legal Date	2022-08-23
Subtype	发明申请
SUSTech Authorship	First
Abstract	本发明公开了一种吲哚啉酮取代的环己二烯酮肟类化合物，其具有通式Ⅰ的结构或通式Ⅰ的对映异构体、非对映异构体：其中，R1选自烷基、‑CH2CH＝CH2、苄基；所述R2选自氢、烷基、烷氧基、卤素、氰基、羟基、氨基、苯基、酯基、醛基、三氟甲基、烯基、炔基、羧基、硝基、酰胺基，n为1～5；所述R3选自氢、烷基、烷氧基、卤素、氰基、羟基、氨基、苯基、酯基、醛基、三氟甲基、烯基、炔基、羧基、硝基、酰胺基，m为1～5。本发明还公开了其合成方法，本发明通过手性磷酸催化的螺氧吲哚和羟胺对映选择性缩合策略，可以高效地获得一类结构新颖多样、立体控制良好的化合物骨架，不仅扩大了轴手性化合物库，而且还为开发新的轴手性骨架奠定了基础。
Other Abstract	The invention discloses an indolinone substituted cyclohexadienone oxime compound, which has a structure as shown in a general formula I or an enantiomer and a diastereomer as shown in the general formula I. In the general formula I, R1 is selected from alkyl,-CH2CH = CH2 and benzyl; r2 is selected from hydrogen, alkyl, alkoxy, halogen, cyano, hydroxyl, amino, phenyl, ester group, aldehyde group, trifluoromethyl, alkenyl, alkynyl, carboxyl, nitryl and acylamino, and n is 1-5; r3 is selected from hydrogen, alkyl, alkoxy, halogen, cyano, hydroxyl, amino, phenyl, ester group, aldehyde group, trifluoromethyl, alkenyl, alkynyl, carboxyl, nitryl and acylamino, and m is 1-5. According to the spirooxindole and hydroxylamine enantioselective condensation strategy catalyzed by chiral phosphoric acid, a compound framework which is novel and diversified in structure and good in three-dimensional control can be efficiently obtained, an axial chiral compound library is expanded, and a foundation is laid for developing a new axial chiral framework.
CPC Classification Number	C07D209/96
IPC Classification Number	C07D209/96
INPADOC Legal Status	（ENTRY INTO FORCE OF REQUEST FOR SUBSTANTIVE EXAMINATION）[2022-08-23][CN]
INPADOC Patent Family Count	1
Extended Patent Family Count	1
Priority date	2022-05-18
Patent Agent	曾敬
Agency	深圳市创富知识产权代理有限公司
URL	[Source Record]
Data Source	PatSnap
Document Type	Patent
Identifier	http://kc.sustech.edu.cn/handle/2SGJ60CL/532868
Department	Academy for Advanced Interdisciplinary Studies
Recommended Citation GB/T 7714	谭斌,朱帅,向少华. 一种吲哚啉酮取代的环己二烯酮肟类化合物及其合成方法.

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