| Title | 小分子抑制剂的新应用 |
| Alternative Title | New application of small molecule inhibitor
|
| Author | |
| First Inventor | 董涛
|
| Original applicant | 南方科技大学
|
| First applicant | 南方科技大学
|
| Address of First applicant | 518055 广东省深圳市南山区桃源街道学苑大道1088号
|
| Current applicant | 南方科技大学
|
| Address of Current applicant | 518055 广东省深圳市南山区桃源街道学苑大道1088号 (广东,深圳,南山区)
|
| First Current Applicant | 南方科技大学
|
| Address of First Current Applicant | 518055 广东省深圳市南山区桃源街道学苑大道1088号 (广东,深圳,南山区)
|
| Application Number | CN202111423070.4
|
| Application Date | 2021-11-26
|
| Open (Notice) Number | CN114159416A
|
| Date Available | 2022-03-11
|
| Status of Patent | 实质审查
|
| Legal Date | 2022-03-29
|
| Subtype | 发明申请
|
| SUSTech Authorship | First
|
| Abstract | 本发明涉及小分子抑制剂的新应用。主要涉及小分子抑制剂在制备抑制霍乱弧菌的药物中的应用，所述小分子抑制剂的化学结构式如式(I)或者式(II)所示：还涉及式(II)所示的小分子抑制剂在制备抑制铜绿假单胞菌、大肠杆菌和金黄色葡萄球菌的药物中的应用。与传统技术相比，本发明具备如下有益效果：发明人筛选到针对霍乱弧菌有明显抑菌效果的化学结构式如式(I)和式(II)所示的小分子抑制剂，为霍乱弧菌的抑制提供了新的手段。并且，式(II)所示小分子抑制剂还能杀灭其他多种病原细菌，包括铜绿假单胞菌、大肠杆菌和金黄色葡萄球菌。 |
| Other Abstract | The invention relates to a novel application of a small molecule inhibitor. Mainly relates to application of a small-molecule inhibitor in preparation of drugs for inhibiting vibrio cholerae, the chemical structural formula of the small-molecule inhibitor is shown as a formula (I) or a formula (II), and the invention also relates to application of the small-molecule inhibitor shown as the formula (II) in preparation of drugs for inhibiting pseudomonas aeruginosa, escherichia coli and staphylococcus aureus. Compared with the prior art, the invention has the following beneficial effects: the inventor screens out small-molecule inhibitors with obvious bacteriostatic effect on vibrio cholerae and with chemical structural formulas as shown in the formula (I) and the formula (II), and provides a new means for inhibition of vibrio cholerae. Moreover, the small-molecule inhibitor shown in the formula (II) can also kill other various pathogenic bacteria, including pseudomonas aeruginosa, escherichia coli and staphylococcus aureus. |
| CPC Classification Number | A61K31/167
; A61K31/517
; A61P31/04
; Y02A50/30
|
| IPC Classification Number | A61K31/167
; A61K31/517
; A61P31/04
|
| INPADOC Legal Status | （ENTRY INTO FORCE OF REQUEST FOR SUBSTANTIVE EXAMINATION）[2022-03-29][CN]
|
| INPADOC Patent Family Count | 1
|
| Extended Patent Family Count | 1
|
| Priority date | 2021-11-26
|
| Patent Agent | 王秉丽
|
| Agency | 华进联合专利商标代理有限公司
|
| URL | [Source Record] |
| Data Source | PatSnap
|
| Document Type | Patent |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/533373 |
| Department | Southern University of Science and Technology |
| Recommended Citation GB/T 7714 |
董涛. 小分子抑制剂的新应用.
|
| Files in This Item: | There are no files associated with this item. | |||||
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