南方科技大学知识苑(SUSTech KC): 一种血管外支架及其应用

Title	一种血管外支架及其应用
Alternative Title	External vascular stent and application thereof
Author	蒋兴宇; 丁力
First Inventor	蒋兴宇
Original applicant	南方科技大学
First applicant	南方科技大学
Address of First applicant	518055 广东省深圳市南山区西丽学苑大道1088号
Current applicant	南方科技大学
Address of Current applicant	518055 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)
First Current Applicant	南方科技大学
Address of First Current Applicant	518055 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)
Application Number	CN202010617498.1
Application Date	2020-06-30
Open (Notice) Number	CN111760179A
Date Available	2020-10-13
Status of Patent	实质审查
Legal Date	2020-10-30
Subtype	发明申请
SUSTech Authorship	First
Abstract	本发明提供了一种血管外支架及其应用，所述血管外支架由层叠设置的支撑层和药物缓释层卷绕而成，所述支撑层包括可降解聚合物A的静电纺丝层，药物缓释层包括药物和可降解聚合物B的静电纺丝层，所述支撑层的降解速率低于药物缓释层的降解速率；该血管外支架中支撑层和药物缓释层均为可降解的纺丝薄膜，一方面纺丝薄膜比较柔软，减少对血管的机械损伤，并通过卷绕，可以增加血管外支架整体的强度和拉伸应力，能够起到较好的置管支撑作用，另一方面二者降解速率不同，使得外支架可以实现短期快速缓释药物的同时并能够提供长期的机械支撑，最终并能够全部降解，消除了潜在的感染和机械损伤的风险。
Other Abstract	The invention provides an external vascular stent and application thereof. The external vascular stent is formed by winding a supporting layer and a drug sustained release layer which are arranged ina stacked mode, the supporting layer comprises an electrostatic spinning layer of a degradable polymer A, the drug sustained release layer comprises an electrostatic spinning layer of a drug and a degradable polymer B, and the degradation rate of the supporting layer is lower than that of the drug sustained release layer. The supporting layer and the drug sustained release layer in the external vascular stent are both degradable spinning films, on one hand, the spinning films are soft, mechanical damage to blood vessels is reduced, the overall strength and tensile stress of the external vascular stent can be improved through winding, and a good catheterization supporting effect can be achieved; on the other hand, the degradation rates of the supporting layer and the drug sustained releaselayer are different, so that the external vascular stent can provide long-term mechanical support while short-term rapid drug sustained release is achieved, finally, the supporting layer and the drugsustained release layer can be completely degraded, and the risks of potential infection and mechanical damage are eliminated.
CPC Classification Number	A61M31/002
IPC Classification Number	A61M31/00
INPADOC Legal Status	（ENTRY INTO FORCE OF REQUEST FOR SUBSTANTIVE EXAMINATION）[2020-10-30][CN]
INPADOC Patent Family Count	1
Extended Patent Family Count	1
Priority date	2020-06-30
Patent Agent	潘登
Agency	北京品源专利代理有限公司
URL	[Source Record]
Data Source	PatSnap
Document Type	Patent
Identifier	http://kc.sustech.edu.cn/handle/2SGJ60CL/533640
Department	Department of Biomedical Engineering
Recommended Citation GB/T 7714	蒋兴宇,丁力. 一种血管外支架及其应用.

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