南方科技大学知识苑(SUSTech KC): 一种金属有机框架材料及其制备方法和应用

Title	一种金属有机框架材料及其制备方法和应用
Alternative Title	Metal organic framework material as well as preparation method and application thereof
Author	蒋兴宇; 陈冕
First Inventor	蒋兴宇
Original applicant	南方科技大学
First applicant	南方科技大学
Address of First applicant	518000 广东省深圳市南山区西丽学苑大道1088号
Current applicant	南方科技大学
Address of Current applicant	518000 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)
First Current Applicant	南方科技大学
Address of First Current Applicant	518000 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)
Application Number	CN201910853441.9
Application Date	2019-09-10
Open (Notice) Number	CN110483802A
Date Available	2019-11-22
Status of Patent	驳回
Legal Date	2022-12-02
Subtype	发明申请
SUSTech Authorship	First
Abstract	本发明涉及一种金属有机框架材料及其制备方法和应用，所述金属有机框架材料包括由中心金属离子和有机配体自组装而成的纳米颗粒；所述中心金属离子包括Zr4+和Ti4+，所述有机配体包括卟啉和/或金属卟啉。所述金属有机框架材料的制备方法包括如下步骤：(a)将PCN‑224纳米颗粒、TiCp2Cl2和溶剂混合，反应后得到所述金属有机框架材料。本发明提供的金属框架有机材料中掺杂有钛离子，与锆离子形成双金属离子团簇，能够促进生成大量活性氧从而增强抗菌活性，可以快速有效的杀死细菌，且在激发态下不容易发生聚集或自猝灭，并且以通过其多孔结构促进生物活性氧的方便扩散，细胞毒性小。
Other Abstract	The invention relates to a metal organic framework material as well as a preparation method and application thereof. The metal organic framework material comprises nanoparticles formed by self-assembly of central metal ions and organic ligands, wherein the central metal ions comprise Zr<4+> and Ti<4+>, and the organic ligand comprises porphyrin and/or metalloporphyrin. The preparation method of the metal organic framework material comprises the following steps: mixing PCN-224 nanoparticles, TiCp2Cl2 and a solvent, and performing a reaction to obtain the metal organic framework material. The metal framework organic material provided by the invention is doped with titanium ions; according to the present invention, the nano-silver and zirconium ions form the bimetallic ion cluster, such thatthe generation of a large amount of the active oxygen can be promoted so as to enhance the antibacterial activity, the bacteria can be rapidly and effectively killed; in addition, aggregation or the self-quenching is not easily generated in the excited state, the convenient diffusion of the biological active oxygen is promoted through the porous structure, and the cytotoxicity is low.
CPC Classification Number	A61L15/18 ; A61L15/20 ; A61L15/26 ; A61L15/42 ; A61L15/46 ; A61L2300/404 ; C08G83/008 ; C08L67/04
IPC Classification Number	C08G83/00 ; A61L15/18 ; A61L15/20 ; A61L15/26 ; A61L15/42 ; A61L15/46
INPADOC Legal Status	（-REJECTION OF INVENTION PATENT APPLICATION AFTER PUBLICATION）[2022-12-02][CN]
INPADOC Patent Family Count	1
Extended Patent Family Count	1
Priority date	2019-09-10
Patent Agent	巩克栋
Agency	北京品源专利代理有限公司
URL	[Source Record]
Data Source	PatSnap
Document Type	Patent
Identifier	http://kc.sustech.edu.cn/handle/2SGJ60CL/533833
Department	Department of Biomedical Engineering
Recommended Citation GB/T 7714	蒋兴宇,陈冕. 一种金属有机框架材料及其制备方法和应用.

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