南方科技大学知识苑(SUSTech KC): 一种大视场高速光声显微成像装置及方法

Title	一种大视场高速光声显微成像装置及方法
Alternative Title	Large-view-field high-speed photoacoustic microscopic imaging device and method
Author	奚磊; 秦伟 ; 齐伟智; 张峻宁; 彭玎陆
First Inventor	奚磊
Original applicant	南方科技大学
First applicant	南方科技大学
Address of First applicant	518055 广东省深圳市南山区桃源街道学苑大道1088号
Current applicant	南方科技大学
Address of Current applicant	518055 广东省深圳市南山区桃源街道学苑大道1088号 (广东,深圳,南山区)
First Current Applicant	南方科技大学
Address of First Current Applicant	518055 广东省深圳市南山区桃源街道学苑大道1088号 (广东,深圳,南山区)
Application Number	CN202111325133.2
Application Date	2021-11-10
Open (Notice) Number	CN114129132A
Date Available	2022-03-04
Status of Patent	实质审查
Legal Date	2022-08-05
Subtype	发明申请
SUSTech Authorship	First
Abstract	本发明公开了一种大视场高速光声显微成像装置及方法。该装置包括激光源组件、光束传输组件、光束扫描组件、反射式成像端口组件及计算机。该方法使用片状光纤束传输脉冲激光器发出的纳秒脉冲激光作为激发光，使用微透镜阵列实现光聚焦，同时激发成像区域单个半径上的光声信号，使用线聚焦超声换能器阵列同时探测单个半径上的光声信号，并结合半径旋转扫描方法实现三维成像。通过半径旋转扫描，将光声显微成像的视场扩展至厘米量级；通过光声信号同时激光、同时采集及重建，将成像时间缩短到秒级，同时实现大视场条件下的高速成像，为动物器官尺度光声成像、大动物光声成像提供条件。
Other Abstract	The invention discloses a large-view-field high-speed photoacoustic microscopic imaging device and a large-view-field high-speed photoacoustic microscopic imaging method. The device comprises a laser source assembly, a light beam transmission assembly, a light beam scanning assembly, a reflective imaging port assembly and a computer. According to the method, nanosecond pulse laser emitted by a sheet-shaped optical fiber bundle transmission pulse laser is used as exciting light, light focusing is achieved through a micro-lens array, meanwhile, photoacoustic signals on a single radius of an imaging area are excited, and the photoacoustic signals on the single radius are detected through a line focusing ultrasonic transducer array at the same time; and a radius rotation scanning method is combined to realize three-dimensional imaging. Expanding a view field of photoacoustic microscopic imaging to a centimeter magnitude through radius rotation scanning; the imaging time is shortened to the second level through simultaneous laser, collection and reconstruction of photoacoustic signals, meanwhile, high-speed imaging under the condition of a large view field is achieved, and conditions are provided for animal organ scale photoacoustic imaging and large animal photoacoustic imaging.
CPC Classification Number	A61B5/0095 ; A61B5/0033 ; A61B5/0035 ; A61B8/5207 ; A61B8/5215 ; A61B8/5261 ; G01N21/1702
IPC Classification Number	A61B5/00 ; A61B8/00 ; G01N21/17
INPADOC Legal Status	（ENTRY INTO FORCE OF REQUEST FOR SUBSTANTIVE EXAMINATION）[2022-08-05][CN]
INPADOC Patent Family Count	1
Extended Patent Family Count	1
Priority date	2021-11-10
URL	[Source Record]
Data Source	PatSnap
Document Type	Patent
Identifier	http://kc.sustech.edu.cn/handle/2SGJ60CL/533868
Department	Department of Biomedical Engineering
Recommended Citation GB/T 7714	奚磊,秦伟,齐伟智,等. 一种大视场高速光声显微成像装置及方法.

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