南方科技大学知识苑(SUSTech KC): 分离芯片

Title	分离芯片
Alternative Title	Separating chip
Author	蒋兴宇; 王赛杰
First Inventor	蒋兴宇
Original applicant	南方科技大学
First applicant	南方科技大学
Address of First applicant	518055 广东省深圳市南山区桃源街道学苑大道1088号
Current applicant	南方科技大学
Address of Current applicant	518055 广东省深圳市南山区桃源街道学苑大道1088号 (广东,深圳,南山区)
First Current Applicant	南方科技大学
Address of First Current Applicant	518055 广东省深圳市南山区桃源街道学苑大道1088号 (广东,深圳,南山区)
Application Number	CN202210799395.0
Application Date	2022-07-08
Open (Notice) Number	CN115337967A
Date Available	2022-11-15
Status of Patent	实质审查
Legal Date	2022-12-02
Subtype	发明申请
SUSTech Authorship	First
Abstract	本申请公开了一种分离芯片，涉及样品分离技术领域；分离芯片包括入口通道，用于接收未稀释的待处理样品；依次连通的至少两个富集分离结构，入口通道与位于最前方的富集分离结构连通，且相邻两个富集分离结构之间的连通处的横截面积逐渐减小，富集分离结构用于从待处理样品中分离得到目标颗粒或用于从待处理样品中分离非目标颗粒以减小下游结构的样品处理压力；通过将未稀释的待处理样品注入到入口通道中，以使得待处理样品经过依次连通的至少两个富集分离结构后实现颗粒的筛选和分离，从而得到目标颗粒；本申请能够从未稀释的待处理样品中分离得到目标颗粒，且能够实现高通量的目标和有效减少杂质以提高目标颗粒的纯度。
Other Abstract	The invention discloses a separation chip, and relates to the technical field of sample separation. The separation chip comprises an inlet channel for receiving an undiluted sample to be treated; the at least two enrichment and separation structures are communicated in sequence, the inlet channel is communicated with the enrichment and separation structure located at the forefront, and the cross sectional area of the communication position between every two adjacent enrichment and separation structures is gradually reduced; the enrichment and separation structure is used for separating target particles from a to-be-treated sample or separating non-target particles from the to-be-treated sample so as to reduce the sample treatment pressure of the downstream structure; an undiluted to-be-treated sample is injected into an inlet channel, so that the to-be-treated sample passes through at least two enrichment and separation structures which are communicated in sequence to realize particle screening and separation, and target particles are obtained; according to the method, the target particles can be separated from the undiluted to-be-treated sample, the high-throughput target can be achieved, and impurities can be effectively reduced so as to improve the purity of the target particles.
IPC Classification Number	B01L3/00
INPADOC Legal Status	（ENTRY INTO FORCE OF REQUEST FOR SUBSTANTIVE EXAMINATION）[2022-12-02][CN]
INPADOC Patent Family Count	1
Extended Patent Family Count	1
Priority date	2022-07-08
Patent Agent	周翀
Agency	广州嘉权专利商标事务所有限公司
URL	[Source Record]
Data Source	PatSnap
Document Type	Patent
Identifier	http://kc.sustech.edu.cn/handle/2SGJ60CL/533965
Department	Department of Biomedical Engineering
Recommended Citation GB/T 7714	蒋兴宇,王赛杰. 分离芯片.

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