南方科技大学知识苑(SUSTech KC): 生物碱氮氮化物衍生物及其制备方法

Title	生物碱氮氮化物衍生物及其制备方法
Alternative Title	Alkaloid nitrogenide derivative and preparation method thereof
Author	刘运根; 支志明; 张世龙
First Inventor	刘运根
Original applicant	南方科技大学
First applicant	南方科技大学
Address of First applicant	518055 广东省深圳市南山区西丽学苑大道1088号
Current applicant	南方科技大学
Address of Current applicant	518055 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)
First Current Applicant	南方科技大学
Address of First Current Applicant	518055 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)
Application Number	CN202010260240.0
Application Date	2020-04-03
Open (Notice) Number	CN111440169A
Date Available	2020-07-24
Status of Patent	实质审查
Legal Date	2020-08-18
Subtype	发明申请
SUSTech Authorship	First
Abstract	本发明涉及一类生物碱氮氮化物及其盐和制备方法，该生物碱氮氮化物及其盐具有潜在的药物应用前景。所述方法以生物碱类天然产物为原料，以苯基羟胺类化合物为氮源，在金属‑有机催化剂的催化作用下，在反应介质中，在常温下，在容器中反应2‑24小时，实现三级胺的胺化反应从而获得所述生物碱氮氮化物，经酸化即可成盐。通过本发明的方法，可以低成本、高产率地获得目标产物，使用的胺化试剂及金属‑有机催化剂廉价易得，反应所用试剂及反应条件对反应原料的官能团耐受性良好，具有广泛的普适性，有希望对生物碱氮氮化物赋予医学研究价值。
Other Abstract	The invention relates to alkaloid nitrogenide and salts thereof and a preparation method. The alkaloid nitrogenide and salts thereof have potential drug application prospects. According to the method,an alkaloid natural product is taken as a raw material, a phenylhydroxylamine compound is taken as a nitrogen source, reaction is carried out in a reaction medium at normal temperature in a containerfor 2-24 hours under the catalytic action of a metal-organic catalyst, amination reaction of tertiary amine is realized, the alkaloid nitrogenide is obtained, and the salt can be formed after acidification. With application of the method, the target product can be obtained with low cost and high yield, the used amination reagent and metal-organic catalyst are cheap and easy to obtain, reagents and reaction conditions used for reaction have good tolerance to functional groups of reaction raw materials, wide universality is achieved, and it is hopeful to give medical research value to alkaloidnitrogen nitride.
CPC Classification Number	C07D471/22 ; C07D221/28 ; C07D491/20 ; C07D453/04 ; C07D455/03 ; C07D519/00 ; C07D493/16 ; C07D221/18 ; C07D491/18 ; C07D491/22 ; C07D491/06 ; C07D451/10 ; C07D221/22 ; C07D487/04 ; C07D223/32 ; C07D471/20 ; A61P35/00 ; C07B2200/07
IPC Classification Number	C07D471/22 ; C07D221/28 ; C07D491/20 ; C07D453/04 ; C07D455/03 ; C07D519/00 ; C07D493/16 ; C07D221/18 ; C07D491/18 ; C07D491/22 ; C07D491/06 ; C07D451/10 ; C07D221/22 ; C07D487/04 ; C07D223/32 ; C07D471/20 ; A61K31/4375 ; A61K31/439 ; A61K31/55 ; A61K31/49 ; A61K31/4745 ; A61K31/4741 ; A61K31/473 ; A61K31/46 ; A61K31/407 ; A61K31/437 ; A61K31/4748 ; A61P35/00
INPADOC Legal Status	（ENTRY INTO FORCE OF REQUEST FOR SUBSTANTIVE EXAMINATION）[2020-08-18][CN]
INPADOC Patent Family Count	1
Extended Patent Family Count	1
Priority date	2020-04-03
Patent Agent	曾敬
Agency	深圳市创富知识产权代理有限公司
URL	[Source Record]
Data Source	PatSnap
Document Type	Patent
Identifier	http://kc.sustech.edu.cn/handle/2SGJ60CL/534000
Department	Department of Chemistry
Recommended Citation GB/T 7714	刘运根,支志明,张世龙. 生物碱氮氮化物衍生物及其制备方法.

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