中文版 | English
Title

一种异钩藤碱在制备具有神经保护作用的药物中的应用

Alternative Title
Application of isorhynchophylline to preparation of medicine with nerve protection effect
Author
First Inventor
杨选军
Original applicant
南方科技大学
First applicant
南方科技大学
Address of First applicant
518000 广东省深圳市南山区西丽学苑大道1088号
Current applicant
南方科技大学
Address of Current applicant
518000 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)
First Current Applicant
南方科技大学
Address of First Current Applicant
518000 广东省深圳市南山区西丽学苑大道1088号 (广东,深圳,南山区)
Application Number
CN201810022687.7
Application Date
2018-01-10
Open (Notice) Number
CN108186637A
Date Available
2018-06-22
Status of Patent
驳回
Legal Date
2021-06-18
Subtype
发明申请
SUSTech Authorship
First
Abstract
本发明提供了一种异钩藤碱在制备具有神经保护作用的药物中的应用,本发明提供的具有神经保护作用的药物,能有效的挽救神经毒素MPTP对多巴胺能神经元的毒性作用,对多巴胺能神经元有保护作用,相比于异钩藤碱常见的降压作用、扩展血管的作用和减慢心率的作用,本发明开发出一种异钩藤碱的新用途,为进一步研究中药材钩藤的神经药理提供了理论依据和实验基础;进一步地,异钩藤碱为治疗帕金森病药物、抗抑郁症药物、治疗阿尔茨海默病药物的开发提供了新的思路和可能;尤其是作为治疗帕金森病的药物,效果尤为突出。
Other Abstract
The invention provides application of isorhynchophylline to preparation of a medicine with a nerve protection effect. The medicine with the nerve protection effect, provided by the invention, can effectively relieve the toxic effect of the neurotoxin MPTP to the dopaminergic neuron and has a protection effect on the dopaminergic neuron. Aiming at the common effects of the isorhynchophylline on reducing blood pressure, expanding blood vessels and slowing down the heart rate, the invention develops new application of the isorhynchophylline and provides a theoretical foundation and an experimental basis for further researching the neuropharmacology of the traditional Chinese medicinal material uncaria; furthermore, the isorhynchophylline provides a new idea and possibility for development ofmedicines for treating Parkinson's disease, medicines for resisting depression and medicines for treating Alzheimer's disease; and particularly, the isorhynchophylline has especially prominent effectsby serving as a medicine for treating Parkinson's disease.
CPC Classification Number
A61K31/438
IPC Classification Number
A61K31/438 ; A61P25/28 ; A61P25/24 ; A61P25/16
INPADOC Legal Status
(-REJECTION OF INVENTION PATENT APPLICATION AFTER PUBLICATION)[2021-06-18][CN]
INPADOC Patent Family Count
1
Extended Patent Family Count
1
Priority date
2018-01-10
Patent Agent
巩克栋
Agency
北京品源专利代理有限公司
URL[Source Record]
Data Source
PatSnap
Document TypePatent
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/534134
DepartmentDepartment of Biology
Recommended Citation
GB/T 7714
杨选军,仲寒冰. 一种异钩藤碱在制备具有神经保护作用的药物中的应用.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Export to Excel
Export to Csv
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[杨选军]'s Articles
[仲寒冰]'s Articles
Baidu Scholar
Similar articles in Baidu Scholar
[杨选军]'s Articles
[仲寒冰]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[杨选军]'s Articles
[仲寒冰]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.