南方科技大学知识苑(SUSTech KC): 一种横向扫描变焦的光学成像方法及系统

Title	一种横向扫描变焦的光学成像方法及系统
Alternative Title	Transverse scanning zooming optical imaging method and system
Author	张昊; 乔良; 钟素艺; 李虹瑾
First Inventor	张昊
Original applicant	南方科技大学
First applicant	南方科技大学
Address of First applicant	518055 广东省深圳市南山区桃源街道学苑大道1088号
Current applicant	南方科技大学
Address of Current applicant	518055 广东省深圳市南山区桃源街道学苑大道1088号 (广东,深圳,南山区)
First Current Applicant	南方科技大学
Address of First Current Applicant	518055 广东省深圳市南山区桃源街道学苑大道1088号 (广东,深圳,南山区)
Application Number	CN202210967260.0
Application Date	2022-08-12
Open (Notice) Number	CN115389472A
Date Available	2022-11-25
Status of Patent	实质审查
Legal Date	2022-12-13
Subtype	发明申请
SUSTech Authorship	First
Abstract	本发明公开了一种横向扫描变焦的光学成像方法及系统，方法包括：以设定扫面范围及扫描速度沿激发光束传播方向轴向扫描荧光光束，以形成具有大视场的光片；沿垂直激发光束传播方向横向扫描荧光光束并与相机的滚动快门同步得到横向扫描图像；将相机采集到的横向扫描图像中的共聚图像进行像素的重新分配及重新组合，以消除光片的旁瓣效应。本发明通过沿光束传播的方向扫描荧光光束，以形成一个具有较大视场的光片，其后与相机的滚动快门同步以实现荧光光束的横向扫描，以在不牺牲荧光光束检测效率的同时增大成像视场，并将扫描得到的图像的共聚图像进行像素的重新分配与重新组合，以消除光片的旁瓣效应，可以在保持高光子效率的同时提高成像分辨率。
Other Abstract	The invention discloses a transverse scanning zoom optical imaging method and system, and the method comprises the steps: axially scanning a fluorescent light beam in the propagation direction of an excitation light beam at a set scanning range and a set scanning speed, so as to form a light sheet with a large field of view; transversely scanning the fluorescent light beam along a direction vertical to the propagation direction of the excitation light beam and synchronizing with a rolling shutter of the camera to obtain a transversely scanned image; and carrying out pixel redistribution and recombination on the copolymerized image in the transverse scanning image acquired by the camera so as to eliminate the side lobe effect of the X-ray plate. The fluorescent light beam is scanned in the light beam propagation direction to form a light sheet with a large view field, and then the light sheet is synchronized with the rolling shutter of the camera to achieve transverse scanning of the fluorescent light beam, so that the imaging view field is enlarged while the detection efficiency of the fluorescent light beam is not sacrificed, and the imaging precision is improved. And pixel redistribution and recombination are carried out on the copolymerized image of the scanned image, so that the side lobe effect of the X-ray plate is eliminated, and the imaging resolution can be improved while the high photon efficiency is kept.
IPC Classification Number	G01N21/64 ; G01N21/01
INPADOC Legal Status	（ENTRY INTO FORCE OF REQUEST FOR SUBSTANTIVE EXAMINATION）[2022-12-13][CN]
INPADOC Patent Family Count	1
Extended Patent Family Count	1
Priority date	2022-08-12
Patent Agent	孙果
Agency	深圳市君胜知识产权代理事务所(普通合伙)
URL	[Source Record]
Data Source	PatSnap
Document Type	Patent
Identifier	http://kc.sustech.edu.cn/handle/2SGJ60CL/534405
Department	Department of Biomedical Engineering
Recommended Citation GB/T 7714	张昊,乔良,钟素艺,等. 一种横向扫描变焦的光学成像方法及系统.

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