Resolvin D1 attenuates depressive-like behavior in LPS-challenged mice by promoting microglial autophagy

Xiong, Wei1,2,3,4; Wang, Han5; Zhang, Hongyan1,2,6; Xing, Yanmei1,2,6; Gao, Wenli1,2,6; Chen, Lengfeng1,2,6; Chen, Lixin7; Dai, Zhongliang1,2,6

2023-04-01

10.1007/s10787-023-01234-9

INFLAMMOPHARMACOLOGY   Impact Factor & Quartile

0925-4692

1568-5608

It has been proven that neuroinflammation triggered by microglial activation is the pathogenesis of depression associated with sepsis. An endogenous lipid mediator known as resolvin D1 (RvD1) is known to have anti-inflammatory effects in a sepsis model. However, it remains unknown if the effects of RvD1 on inflammatory responses are regulated by microglial autophagy. The current study investigated the role of RvD1-induced microglial autophagy in neuroinflammation. The findings showed that RvD1 reverses LPS-induced autophagy inhibition in microglia. RvD1 treatment significantly inhibits inflammatory responses by preventing NF-kappa B nuclear translocation and microglial M1 phenotypic transition. RvD1 exhibits an attenuation of neurotoxicity in both in vivo and in vitro models of sepsis. Following RvD1 injection, depressive-like behaviors in SAE mice were significantly improved. Notably, the aforesaid effects of RvD1 were eliminated by 3-MA, demonstrating that microglial autophagy was modulated. In conclusion, our findings shed new light on the involvement of microglial autophagy in SAE and emphasize the potential benefits of RvD1 as a promising therapeutic agent in the treatment of depression.

Resolvin D1 Neurotoxicity Autophagy Sepsis Depression Neuroinflammation

SCI

English

Corresponding

National Natural Science Foundation of China[81902016] ; Natural Science Foundation of Guangdong[2022A1515012129] ; Shenzhen Municipal Science and Technology Foundation[JCYJ20220530152615035]

Immunology ; Pharmacology & Pharmacy ; Toxicology

Immunology ; Pharmacology & Pharmacy ; Toxicology

WOS:000980141900002

SPRINGER BASEL AG

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Anesthesiol, 1017 Dongmen North Rd, Shenzhen 518020, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, 1017 Dongmen North Rd, Shenzhen 518020, Peoples R China
3.Jinan Univ, Integrated Chinese & Western Med Postdoctoral Res, Guangzhou, Peoples R China
4.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Crit Care Med, Wuhan, Peoples R China
5.Qingdao Univ, Qingdao Women & Childrens Hosp, Dept Anesthesiol, Qingdao, Peoples R China
6.Shenzhen Peoples Hosp, Shenzhen Clin Res Ctr Geriatr, Shenzhen, Peoples R China
7.Jinan Univ, Med Coll, Dept Pharmacol, Guangzhou, Peoples R China

Xiong, Wei,Wang, Han,Zhang, Hongyan,et al. Resolvin D1 attenuates depressive-like behavior in LPS-challenged mice by promoting microglial autophagy[J]. INFLAMMOPHARMACOLOGY,2023.

Xiong, Wei.,Wang, Han.,Zhang, Hongyan.,Xing, Yanmei.,Gao, Wenli.,...&Dai, Zhongliang.(2023).Resolvin D1 attenuates depressive-like behavior in LPS-challenged mice by promoting microglial autophagy.INFLAMMOPHARMACOLOGY.

Xiong, Wei,et al."Resolvin D1 attenuates depressive-like behavior in LPS-challenged mice by promoting microglial autophagy".INFLAMMOPHARMACOLOGY (2023).