Visual Multifunctional Aggregation-Induced Emission-Based Bacterial Cellulose for Killing of Multidrug-Resistant Bacteria
|Corresponding Author||Wang，Dong; Li，Ying; Tang，Ben Zhong|
Multidrug-resistant (MDR) bacteria-related wound infections are a thorny issue. It is urgent to develop new antibacterial wound dressings that can not only prevent wounds from MDR bacteria infection but also promote wound healing. Herein, an aggregation-induced emission (AIE) molecule BITT-composited bacterial cellulose (BC) is presented as wound dressings. BC-BITT composites have good transparency, making it easy to monitor the wound healing process through the composite membrane. The BC-BITT composites retain the advantages of biocompatible BC, and display photodynamic and photothermal synergistic antibacterial effects under irradiation of a 660 nm laser. Furthermore, the BC-BITT composites show excellent wound healing performance in a mouse full-thickness skin wound model infected by MDR bacteria, simultaneously with negligible toxicity. This work paves a way for treating clinically troublesome wound infections.
|WOS Accession No|
Cited Times [WOS]:0
|Document Type||Journal Article|
|Department||Department of Biomedical Engineering|
1.Center for AIE Research,Shenzhen Key Laboratory of Polymer Science and Technology,Guangdong Research Center for Interfacial Engineering of Functional Materials,College of Materials Science and Engineering,Shenzhen University,Shenzhen,518060,China
2.Key Laboratory of Advanced Textile Materials and Manufacturing Technology and Engineering Research Center for Eco-Dyeing and Finishing of Textiles,Ministry of Education,Zhejiang Provincial Engineering Research Center for Green and Low-carbon Dyeing and Finishing,Zhejiang Sci-Tech University,Hangzhou,310018,China
3.CAS Key Laboratory of Quantitative Engineering Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,China
4.Department of Biomedical Engineering,Southern University of Science and Technology Shenzhen,Guangdong,518055,China
5.Department of Biomedical Engineering,College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan,430074,China
6.Innovation Research Center for AIE Pharmaceutical Biology,Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology,the NMPA and State Key Laboratory of Respiratory Disease,School of Pharmaceutical Sciences and the Fifth Affiliated Hospital,Guangzhou Medical University,Guangzhou,511436,China
7.Shenzhen Institute of Molecular Aggregate Science and Engineering,School of Science and Engineering,The Chinese University of Hong Kong,Shenzhen,518172,China
Shen，Zipeng,Zhu，Wei,Huang，Yajia,et al. Visual Multifunctional Aggregation-Induced Emission-Based Bacterial Cellulose for Killing of Multidrug-Resistant Bacteria[J]. Advanced Healthcare Materials,2023.
Shen，Zipeng.,Zhu，Wei.,Huang，Yajia.,Zhang，Jiangjiang.,Wu，Yifan.,...&Tang，Ben Zhong.(2023).Visual Multifunctional Aggregation-Induced Emission-Based Bacterial Cellulose for Killing of Multidrug-Resistant Bacteria.Advanced Healthcare Materials.
Shen，Zipeng,et al."Visual Multifunctional Aggregation-Induced Emission-Based Bacterial Cellulose for Killing of Multidrug-Resistant Bacteria".Advanced Healthcare Materials (2023).
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