Inflammatory Bowel Disease and Risk of Global Cardiovascular Diseases and Type 2 Diabetes

Zhu, Zhengbao1,2,3; Jia, Yiming1,2; Li, Fu-Rong4; Li, Yang5; Chen, Li-Hua6; Yang, Huan-Huan7; Guo, Daoxia1,2,8; Sun, Lulu1,2; Shi, Mengyao1,2,3; Wang, Tao5; Rohan, Thomas E.5; Qi, Qibin5; Qin, Li-Qiang2,9; Zhang, Yonghong1,2; Chen, Guo-Chong2,9,10,11

2023-08-14

10.1093/ibd/izad163

INFLAMMATORY BOWEL DISEASES   Impact Factor & Quartile

1078-0998

1536-4844

Background Inflammatory bowel disease (IBD) was associated with elevated risk of cardiometabolic diseases in observational studies. We aimed to evaluate the observational and genetic associations of Crohn's disease (CD) and ulcerative colitis (UC) with multiple cardiometabolic outcomes.Methods Our phenotypic and genetic association analyses included more than 400 000 participants who were free of major cardiovascular disease and diabetes at recruitment (2006-2010) and were followed up until December 2019 based on the UK Biobank. For the Mendelian randomization (MR) analyses, 415 and 273 single nucleotide polymorphisms associated with CD and UC, respectively, were selected as genetic instruments. Summary-level data on individual cardiometabolic outcomes were obtained from 4 different genome-wide association studies with a total of 2 248 842 participants.Results In the multivariable-adjusted observational analyses, CD was associated with higher risks of heart failure (hazard ratio [HR], 1.72; 95% confidence interval, 1.22-2.42) and type 2 diabetes (HR, 2.11; 95% confidence interval, 1.67-2.67) but not with myocardial infarction or ischemic stroke. UC was related to increased risks of all the assessed cardiometabolic diseases (HRs ranged from 1.29 for myocardial infarction to 1.76 for type 2 diabetes). Conversely, neither the genetic risk score for CD nor that for UC was associated with higher risk of developing cardiometabolic diseases. In 2-sample MR analyses, genetically determined CD and UC were not associated with any of the assessed cardiometabolic diseases (all P values >.05).Conclusions Despite confirming the observational associations, our study does not support a causal association between IBD and elevated risk of cardiometabolic diseases.

cardiovascular disease causality Crohn's disease ulcerative colitis type 2 diabetes

SCI

English

Others

null[60009]

Gastroenterology & Hepatology

Gastroenterology & Hepatology

WOS:001056797100001

OXFORD UNIV PRESS INC

CLINICAL MEDICINE

Web of Science

1.Soochow Univ, Suzhou Med Coll, Sch Publ Hlth, Dept Epidemiol, Suzhou, Peoples R China
2.Soochow Univ, Jiangsu Key Lab Prevent & Translat Med Geriatr Dis, Suzhou Med Coll, Suzhou, Peoples R China
3.Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA
4.Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen, Peoples R China
5.Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY USA
6.Nantong Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Nantong, Peoples R China
7.Tsinghua Univ, Vanke Sch Publ Hlth, Beijing, Peoples R China
8.Soochow Univ, Suzhou Med Coll, Sch Nursing, Suzhou, Peoples R China
9.Soochow Univ, Suzhou Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg, Suzhou, Peoples R China
10.Soochow Univ, Suzhou Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg, 199 Renai Rd,Ind Pk Dist, Suzhou 215123, Jiangsu, Peoples R China
11.Soochow Univ, Suzhou Med Coll, Jiangsu Key Lab Prevent & Translat Med Geriatr Dis, 199 Renai Rd,Ind Pk Dist, Suzhou 215123, Jiangsu, Peoples R China

Zhu, Zhengbao,Jia, Yiming,Li, Fu-Rong,et al. Inflammatory Bowel Disease and Risk of Global Cardiovascular Diseases and Type 2 Diabetes[J]. INFLAMMATORY BOWEL DISEASES,2023.

Zhu, Zhengbao.,Jia, Yiming.,Li, Fu-Rong.,Li, Yang.,Chen, Li-Hua.,...&Chen, Guo-Chong.(2023).Inflammatory Bowel Disease and Risk of Global Cardiovascular Diseases and Type 2 Diabetes.INFLAMMATORY BOWEL DISEASES.

Zhu, Zhengbao,et al."Inflammatory Bowel Disease and Risk of Global Cardiovascular Diseases and Type 2 Diabetes".INFLAMMATORY BOWEL DISEASES (2023).