Design principles in mechanically adaptable biomaterials for repairing annulus fibrosus rupture: A review
|Corresponding Author||Liu，Hongmei; Zheng，Zhaomin; Wu，Decheng|
Annulus fibrosus (AF) plays a crucial role in the biomechanical loading of intervertebral disc (IVD). AF is difficult to self-heal when the annulus tears develop, because AF has a unique intricate structure and biologic milieu in vivo. Tissue engineering is promising for repairing AF rupture, but construction of suitable mechanical matching devices or scaffolds is still a grand challenge. To deeply know the varied forces involved in the movement of the native annulus is highly beneficial for designing biomimetic scaffolds to recreate the AF function. In this review, we overview six freedom degrees of forces and adhesion strength on AF tissue. Then, we summarize the mechanical modalities to simulate related forces on AF and to assess the characteristics of biomaterials. We finally outline some current advanced techniques to develop mechanically adaptable biomaterials for AF rupture repair.
First ; Corresponding
Ministry of Science and Technology[2020YFA0908900];Basic and Applied Basic Research Foundation of Guangdong Province[2022A1515110321];National Natural Science Foundation of China;National Natural Science Foundation of China;Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20220818100601003];Science, Technology and Innovation Commission of Shenzhen Municipality[KQTD20200820113012029];
|WOS Research Area|
Engineering ; Materials Science
Engineering, Biomedical ; Materials Science, Biomaterials
|WOS Accession No|
Cited Times [WOS]:0
|Document Type||Journal Article|
|Department||Department of Biomedical Engineering|
1.Guangdong Provincial Key Laboratory of Advanced Biomaterials,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.Department of Spine Surgery,The First Affiliated Hospital,Sun Yat-Sen University,Guangzhou,510080,China
3.Pain Research Center,Sun Yat-Sen University,Guangzhou,510080,China
|First Author Affilication||Department of Biomedical Engineering|
|Corresponding Author Affilication||Department of Biomedical Engineering|
|First Author's First Affilication||Department of Biomedical Engineering|
Zhou，Dan,Liu，Hongmei,Zheng，Zhaomin,et al. Design principles in mechanically adaptable biomaterials for repairing annulus fibrosus rupture: A review[J]. Bioactive Materials,2024,31:422-439.
Zhou，Dan,Liu，Hongmei,Zheng，Zhaomin,&Wu，Decheng.(2024).Design principles in mechanically adaptable biomaterials for repairing annulus fibrosus rupture: A review.Bioactive Materials,31,422-439.
Zhou，Dan,et al."Design principles in mechanically adaptable biomaterials for repairing annulus fibrosus rupture: A review".Bioactive Materials 31(2024):422-439.
|Files in This Item:||There are no files associated with this item.|
|Recommend this item|
|Export to Endnote|
|Export to Excel|
|Export to Csv|
|Similar articles in Google Scholar|
|Similar articles in Baidu Scholar|
|Similar articles in Bing Scholar|
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.