Unraveling the differential perturbations of species-level functional profiling of gut microbiota among phases of methamphetamine-induced conditioned place preference

Wang，Yinan1,2; Guo，Zhonghao3; Li，Jing4; Sui，Fang5; Dai，Wenkui1; Zhang，Wenyong2; Du，Hui1

2023-12-20

10.1016/j.pnpbp.2023.110828

Progress in Neuro-Psychopharmacology and Biological Psychiatry   Impact Factor & Quartile

0278-5846

1878-4216

The gut microbiome plays a significant role in methamphetamine addiction. Previous studies using short-read amplicon sequencing have described alterations in microbiota at the genus level and predicted function, in which taxonomic resolution is insufficient for accurate functional measurements. To address this limitation, we employed metagenome sequencing to intuitively associate species to functions of gut microbiota in methamphetamine-induced conditioned place preference. We observed differential perturbations of species-level functional profiling of the gut microbiota across phases of METH-induced CPP, with alterations in SCFA metabolism and bacterial motility at the acquisition phase and substance dependence-alcoholism pathway and amino acid metabolism at the extinction phase. Our findings suggest that reduced beneficial bacteria, i.e., Lactobacillus reuteri, contributed to the alteration of SCFA metabolism, while the increased abundance of Akkermansia muciniphila during the extinction phase may be associated with altered phenylalanine, tyrosine, and tryptophan metabolism and substance dependence pathway. Our study further supports the association between specific microbial taxa and METH-induced rewarding.

Conditioned place preference Gut microbiota Metagenome sequencing Methamphetamine

SCI

English

Corresponding

Peking University[KYQD2022209];

Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry

Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry

WOS:001068738300001

PERGAMON-ELSEVIER SCIENCE LTD

NEUROSCIENCE & BEHAVIOR

2-s2.0-85165239031

Scopus

1.Department of Obstetrics and Gynecology,Peking University Shenzhen Hospital,Shenzhen,China
2.School of Medicine,Southern University of Science and Technology,Shenzhen,China
3.School of Medicine,Xi'an Jiaotong University,Xi'an,China
4.University of Science and Technology of China,Anhui,China
5.Department of Otorhinolaryngology-Head and Neck Surgery,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,China

Wang，Yinan,Guo，Zhonghao,Li，Jing,et al. Unraveling the differential perturbations of species-level functional profiling of gut microbiota among phases of methamphetamine-induced conditioned place preference[J]. Progress in Neuro-Psychopharmacology and Biological Psychiatry,2023,127.

Wang，Yinan.,Guo，Zhonghao.,Li，Jing.,Sui，Fang.,Dai，Wenkui.,...&Du，Hui.(2023).Unraveling the differential perturbations of species-level functional profiling of gut microbiota among phases of methamphetamine-induced conditioned place preference.Progress in Neuro-Psychopharmacology and Biological Psychiatry,127.

Wang，Yinan,et al."Unraveling the differential perturbations of species-level functional profiling of gut microbiota among phases of methamphetamine-induced conditioned place preference".Progress in Neuro-Psychopharmacology and Biological Psychiatry 127(2023).