Construction of fluorescent sensor array and three-dimensional microfluidic paper based analytical device for specific identification and visual determination of antibiotics in food

Li，Tingting1; Guo，Guoqiang1; Xing，Haoming1; Tang，Siyuan1,2; Hu，Houwen1; Wang，Linfan1; Qian，Xiaoqing1; Chen，Da1

2023-12-15

10.1016/j.foodchem.2023.136947

Food Chemistry   Impact Factor & Quartile

0308-8146

1873-7072

For antibiotics misuse since the global outbreak of COVID 19, a novel strategy for discriminating and detecting antibiotics is proposed based on the graphene quantum dots with multi-doped heteroatoms including F, N and P (M-GQDs), which exhibit blue emission (419.0 nm) under the excitation of 336.0 nm. Specifically, the fluorescence of M-GQDs is quenched by tetracyclines (TCs) owing to inner filter effect (IFE) and enhanced by alkane-modified fluoroquinolones (AFQs), which is attributed to restricted conformational rotation based on π-π stacking, hydrogen-bonding and electrostatic interactions. Meanwhile, the electron-accepting property of oxazine ring in oxazine-modified fluoroquinolones (OFQs) increases emission peak at 498.0 nm and decreases emission peak at 419.0 nm as the color changes from blue to cyan. Moreover, a cascade system integrated with 3D microfluidic paper‐based analytical device (3D-μPAD) is applied successfully for visually distinguishing three antibiotics, which shows great potential and versatility of M-GQDs for food safety monitoring.

3D microfluidic paper‐based analytical device Antibiotics Determination Graphene quantum dots Visual differentiation

SCI

English

Others

National Natural Science Foundation of China[61604084];

Chemistry ; Food Science & Technology ; Nutrition & Dietetics

Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics

WOS:001049493800001

ELSEVIER SCI LTD

AGRICULTURAL SCIENCES

2-s2.0-85165536251

Scopus

1.Department of Microelectronic Science and Engineering,School of Physical Science and Technology,Ningbo University,Ningbo,315211,China
2.Department of Materials Science and Engineering,Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG),Southern University of Science and Technology,Shenzhen,518055,China

Li，Tingting,Guo，Guoqiang,Xing，Haoming,et al. Construction of fluorescent sensor array and three-dimensional microfluidic paper based analytical device for specific identification and visual determination of antibiotics in food[J]. Food Chemistry,2023,429.

Li，Tingting.,Guo，Guoqiang.,Xing，Haoming.,Tang，Siyuan.,Hu，Houwen.,...&Chen，Da.(2023).Construction of fluorescent sensor array and three-dimensional microfluidic paper based analytical device for specific identification and visual determination of antibiotics in food.Food Chemistry,429.

Li，Tingting,et al."Construction of fluorescent sensor array and three-dimensional microfluidic paper based analytical device for specific identification and visual determination of antibiotics in food".Food Chemistry 429(2023).