Locating causal hubs of memory consolidation in spontaneous brain network in male mice

Li，Zengmin1; Athwal，Dilsher1; Lee，Hsu Lei1; Sah，Pankaj1,2; Opazo，Patricio1,3,4; Chuang，Kai Hsiang1,5,6

2023-12-01

10.1038/s41467-023-41024-z

Nature Communications   Impact Factor & Quartile

2041-1723

Memory consolidation after learning involves spontaneous, brain-wide network reorganization during rest and sleep, but how this is achieved is still poorly understood. Current theory suggests that the hippocampus is pivotal for this reshaping of connectivity. Using fMRI in male mice, we identify that a different set of spontaneous networks and their hubs are instrumental in consolidating memory during post-learning rest. We found that two types of spatial memory training invoke distinct functional connections, but that a network of the sensory cortex and subcortical areas is common for both tasks. Furthermore, learning increased brain-wide network integration, with the prefrontal, striatal and thalamic areas being influential for this network-level reconfiguration. Chemogenetic suppression of each hub identified after learning resulted in retrograde amnesia, confirming the behavioral significance. These results demonstrate the causal and functional roles of resting-state network hubs in memory consolidation and suggest that a distributed network beyond the hippocampus subserves this process.

SCI

English

NI Journal Papers

Others

Australian Research Council[DP180103319];

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:001063751200026

NATURE PORTFOLIO

2-s2.0-85169760627

Scopus

1.Queensland Brain Institute,The University of Queensland,Brisbane,Australia
2.Joint Center for Neuroscience and Neural Engineering,and Department of Biology,Southern University of Science and Technology,Shenzhen,Guangdong,China
3.Clem Jones Centre for Ageing Dementia Research,The University of Queensland,Brisbane,Australia
4.UK Dementia Research Institute,Centre for Discovery Brain Sciences,The University of Edinburgh,Edinburgh,United Kingdom
5.Centre of Advanced Imaging,The University of Queensland,Brisbane,Australia
6.Australian Research Council Training Centre for Innovation in Biomedical Imaging Technology,Brisbane,Australia

Li，Zengmin,Athwal，Dilsher,Lee，Hsu Lei,et al. Locating causal hubs of memory consolidation in spontaneous brain network in male mice[J]. Nature Communications,2023,14(1).

Li，Zengmin,Athwal，Dilsher,Lee，Hsu Lei,Sah，Pankaj,Opazo，Patricio,&Chuang，Kai Hsiang.(2023).Locating causal hubs of memory consolidation in spontaneous brain network in male mice.Nature Communications,14(1).

Li，Zengmin,et al."Locating causal hubs of memory consolidation in spontaneous brain network in male mice".Nature Communications 14.1(2023).