Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer

Yu，Shuyong1; Tu，Ruisha1; Chen，Zhaowei2; Song，Jian2; Li，Ping3; Hu，Feixiang1; Yuan，Guihong2; Zhang，Ronglin3; Li，Yini3

2023-12-01

10.1186/s12920-023-01645-1

BMC Medical Genomics   Impact Factor & Quartile

1755-8794

Background: Gastric cancer (GC) is one of the most common malignancies, affected by several genetic loci in the clinical phenotype. This study aimed to determine the association between PTGER4 and PRKAA1 gene polymorphisms and the risk of GC. Methods: A total of 509 GC patients and 507 age and sex-matched healthy controls were recruited to explore the association between PTGER4 and PRKAA1 genetic polymorphisms and GC susceptibility. Logistic regression analysis was used to study the correlation between these SNPs and GC, with odd ratio (OR) and 95% confidence interval (CI) as indicators. Multifactor dimensionality reduction was utilized to analyze the genetic relationships among SNPs. was conducted to predict gene expression, the impact of SNPs on gene expression, and the signaling pathways involved in PTGER4 and PRKAA1. Results: Overall, rs10036575 in PTGER4 (OR = 0.82, p = 0.029), rs10074991 (OR = 0.82, p = 0.024) and rs13361707 (OR = 0.82, p = 0.030) in PRKAA1 were associated with susceptibility to GC. Stratification analysis revealed that the effects of these SNPs in PTGER4 and PRKAA1 on GC susceptibility were dependent on smoking and were associated with a reduced risk of adenocarcinoma (p < 0.05). Bioinformatics analysis showed an association between SNPs and corresponding gene expression (p < 0.05), and PRKAA1 may affect GC by mediating RhoA. Conclusion: This study suggests that PTGER4 and PRKAA1 SNPs might affect the susceptibility of GC, providing a new biological perspective for GC risk assessment, pathogenesis exploration, and personalized treatment.

Gastric cancer PRKAA1 polymorphisms PTGER4 polymorphisms Stratification analysis

SCI

English

Corresponding

Genetics & Heredity

Genetics & Heredity

WOS:001062176100001

BMC

2-s2.0-85169705881

Scopus

1.Department of Gastrointestinal Surgery,Hainan Cancer Hospital,Haikou,Hainan,570312,China
2.Department of Gastroenterology,Southern University of Science and Technology Hospital,Shenzhen,518055,China
3.Department of Digestive Endoscopy,Hainan Cancer Hospital,Haikou,Hainan,570312,China

Yu，Shuyong,Tu，Ruisha,Chen，Zhaowei,et al. Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer[J]. BMC Medical Genomics,2023,16(1).

Yu，Shuyong.,Tu，Ruisha.,Chen，Zhaowei.,Song，Jian.,Li，Ping.,...&Li，Yini.(2023).Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer.BMC Medical Genomics,16(1).

Yu，Shuyong,et al."Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer".BMC Medical Genomics 16.1(2023).