Genetic risk, adherence to healthy lifestyle and acute cardiovascular and thromboembolic complications following SARS-COV-2 infection
Current understanding of determinants for COVID-19-related cardiovascular and thromboembolic (CVE) complications primarily covers clinical aspects with limited knowledge on genetics and lifestyles. Here, we analysed a prospective cohort of 106,005 participants from UK Biobank with confirmed SARS-CoV-2 infection. We show that higher polygenic risk scores, indicating individual’s hereditary risk, were linearly associated with increased risks of post-COVID-19 atrial fibrillation (adjusted HR 1.52 [95% CI 1.44 to 1.60] per standard deviation increase), coronary artery disease (1.57 [1.46 to 1.69]), venous thromboembolism (1.33 [1.18 to 1.50]), and ischaemic stroke (1.27 [1.05 to 1.55]). These genetic associations are robust across genders, key clinical subgroups, and during Omicron waves. However, a prior composite healthier lifestyle was consistently associated with a reduction in all outcomes. Our findings highlight that host genetics and lifestyle independently affect the occurrence of CVE complications in the acute infection phrase, which can guide tailored management of COVID-19 patients and inform population lifestyle interventions to offset the elevated cardiovascular burden post-pandemic.
NI Journal Papers
NIHR Senior Research Fellowship[SRF-2018-11-ST2-004]
|WOS Research Area|
Science & Technology - Other Topics
|WOS Accession No|
Cited Times [WOS]:0
|Document Type||Journal Article|
|Department||Department of Pharmacology|
1.Centre for Statistics in Medicine and NIHR Biomedical Research Centre Oxford,NDORMS,University of Oxford,Oxford,United Kingdom
2.Botnar Research Centre,Nuffield Department of Orthopaedics,Rheumatology and Musculoskeletal Sciences,University of Oxford,Oxford,United Kingdom
3.Department of Pharmacology,School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong,China
4.Department Non-communicable Disease Epidemiology,London School of Hygiene & Tropical Medicine,London,United Kingdom
5.Nuffield Department of Population Health,University of Oxford,Oxford,United Kingdom
6.Medical Research Council Epidemiology Unit,University of Cambridge,Cambridge,United Kingdom
7.Department of Infectious Diseases Department & irsiCaixa AIDS Research Institute,Hospital Universitari Germans 13 Trias i Pujol,Catalonia,Spain
8.Center for Global Health and Diseases,Department of Pathology,Case Western Reserve University School of Medicine,Cleveland,United States
9.Department of Medical Informatics,Erasmus Medical Center University,Rotterdam,Netherlands
Xie，Junqing,Feng，Yuliang,Newby，Danielle,et al. Genetic risk, adherence to healthy lifestyle and acute cardiovascular and thromboembolic complications following SARS-COV-2 infection[J]. Nature Communications,2023,14(1).
Xie，Junqing.,Feng，Yuliang.,Newby，Danielle.,Zheng，Bang.,Feng，Qi.,...&Prieto-Alhambra，Daniel.(2023).Genetic risk, adherence to healthy lifestyle and acute cardiovascular and thromboembolic complications following SARS-COV-2 infection.Nature Communications,14(1).
Xie，Junqing,et al."Genetic risk, adherence to healthy lifestyle and acute cardiovascular and thromboembolic complications following SARS-COV-2 infection".Nature Communications 14.1(2023).
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