Stem cell-derived intestinal organoids: a novel modality for IBD

Tian，Cheng mei1,2; Yang，Mei feng3; Xu，Hao ming4; Zhu，Min zheng4; Yue，Ning Ning5; Zhang，Yuan6; Shi，Rui yue1; Yao，Jun1; Wang，Li sheng1; Liang，Yu jie7; Li，De feng1

2023-12-01

10.1038/s41420-023-01556-1

Cell Death Discovery   Impact Factor & Quartile

2058-7716

The organoids represent one of the greatest revolutions in the biomedical field in the past decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly similar to that of the tissue and organ. Using the regeneration ability of stem cells, a 3D organ-like structure called intestinal organoids is established, which can mimic the characteristics of real intestinal organs, including morphology, function, and personalized response to specific stimuli. Here, we discuss current stem cell-based organ-like 3D intestinal models, including understanding the molecular pathophysiology, high-throughput screening drugs, drug efficacy testing, toxicological evaluation, and organ-based regeneration of inflammatory bowel disease (IBD). We summarize the advances and limitations of the state-of-the-art reconstruction platforms for intestinal organoids. The challenges, advantages, and prospects of intestinal organs as an in vitro model system for precision medicine are also discussed. [Figure not available: see fulltext.]

SCI

English

First ; Corresponding

Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20190807145617113];Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20210324113802006];

Cell Biology

Cell Biology

WOS:001035663000001

SPRINGERNATURE

2-s2.0-85165310857

Scopus

1.Department of Gastroenterology,Shenzhen People’s Hospital,The Second Clinical Medical College,Jinan University; The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China
2.Department of Emergency,Shenzhen People’s Hospital,The Second Clinical Medical College,Jinan University; The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China
3.Department of Hematology,Yantian District People’s Hospital,Shenzhen,Guangdong,518020,China
4.Department of Gastroenterology and Hepatology,Guangzhou Digestive Disease Center,Guangzhou First People’s Hospital,School of Medicine,South China University of Technology,Guangzhou,51000,China
5.Department of Gastroenterology,Shenzhen People’s Hospital The Second Clinical Medical College,Jinan University,Shenzhen,Guangdong,518020,China
6.Department of Medical Administration,Huizhou Institute of Occupational Diseases Control and Prevention,Huizhou,Guangdong,516000,China
7.Department of Child and Adolescent Psychiatry,Shenzhen Kangning Hospital,Shenzhen,Guangdong,518020,China

Tian，Cheng mei,Yang，Mei feng,Xu，Hao ming,et al. Stem cell-derived intestinal organoids: a novel modality for IBD[J]. Cell Death Discovery,2023,9(1).

Tian，Cheng mei.,Yang，Mei feng.,Xu，Hao ming.,Zhu，Min zheng.,Yue，Ning Ning.,...&Li，De feng.(2023).Stem cell-derived intestinal organoids: a novel modality for IBD.Cell Death Discovery,9(1).

Tian，Cheng mei,et al."Stem cell-derived intestinal organoids: a novel modality for IBD".Cell Death Discovery 9.1(2023).