Vitamins in neuropathy: pathophysiological and therapeutic roles

Chen，Peng1; Song，Xue Jun2

2023-10-01

10.1097/WCO.0000000000001194

Current opinion in neurology   Impact Factor & Quartile

1350-7540

1473-6551

PURPOSE OF REVIEW: Vitamin deficiency is a risk factor in the development of peripheral neuropathy, which leads to complex and severe diseases. This review provides an update overview of the literature on the roles of vitamins in peripheral neuropathy, highlighting their pathophysiological and therapeutic roles. RECENT FINDINGS: The importance and clinical manifestations and implications of the vitamins and vitamin deficiencies are further demonstrated in peripheral neuropathy and the associated diseases. Vitamin deficiency is common in various severe and complex diseases such as diabetes, chemotherapy, acute nutritional axonal neuropathy, dermatitis, complex regional pain syndrome, postherpetic neuralgia, carpal tunnel syndrome, and so forth and some rare clinical case reports. There is evidence that deficiencies of almost all vitamins are associated with diabetic neuropathy. Vitamin supplementation may serve as an effective therapeutic strategy. SUMMARY: The vitamins play critical roles in maintaining physiological functions, and vitamin deficiencies cause peripheral neuropathy with various severe and complex diseases. The therapeutic benefits of vitamins and further understanding of the mechanisms for vitamin treatment effects should be emphasized and highlighted. More clinical trials are needed to establish optimal treatment strategies for vitamins in the various neuropathies. A large range of people/patients screening for vitamin deficiencies may be considered in order to provide early diagnosis and timely medical assistance.

chemotherapy diabetes neuralgia polyneuropathy vitamins

SCI

English

First

Foundation of Shenzhen Science and Technology Innovation Committee[NSFC81971062] ; null[JCYJ20200109 141433384]

Neurosciences & Neurology

Clinical Neurology ; Neurosciences

WOS:001070559000004

LIPPINCOTT WILLIAMS & WILKINS

NEUROSCIENCE & BEHAVIOR

2-s2.0-85170294366

Scopus

1.Department of Medical Neuroscience and SUSTech Center for Pain Medicine,School of Medicine,Southern University of Science and Technology,Shenzhen,China
2.

Chen，Peng,Song，Xue Jun. Vitamins in neuropathy: pathophysiological and therapeutic roles[J]. Current opinion in neurology,2023,36(5):388-393.

Chen，Peng,&Song，Xue Jun.(2023).Vitamins in neuropathy: pathophysiological and therapeutic roles.Current opinion in neurology,36(5),388-393.

Chen，Peng,et al."Vitamins in neuropathy: pathophysiological and therapeutic roles".Current opinion in neurology 36.5(2023):388-393.