| Title | Rapidly in situ forming an injectable Chitosan/PEG hydrogel for intervertebral disc repair |
| Author | |
| Corresponding Author | Liu，Hongmei; Zheng，Zhaomin; Wu，Decheng |
| Publication Years | 2023-10-01
|
| DOI | |
| Source Title | |
| ISSN | 2590-0064
|
| EISSN | 2590-0064
|
| Volume | 22 |
| Abstract | Intervertebral disc (IVD) degeneration occurred with the increasing age or accidents has puzzled peoples in daily life. To seal IVD defect by injectable hydrogels is a promising method for slowing down IVD degeneration. Herein, we reported a rapidly in situ forming injectable chitosan/PEG hydrogel (CSMA-PEGDA-L) through integrating photo-crosslink of methacrylate chitosan (CSMA) with Schiff base reaction between CSMA and aldehyde polyethylene glycol (PEGDA). The CSMA-PEGDA-L possessed a stronger compressive strength than the photo-crosslinked CSMA-L hydrogel and Schiff-base-crosslinked CSMA-PEGDA hydrogel. This chitosan/PEG hydrogel showed low cytotoxicity from incubation experiments of nucleus pulpous cells. When implanted on the punctured IVD of rat's tail, the CSMA-PEGDA-L hydrogel could well retard the progression of IVD degeneration through physical plugging, powerfully proven by radiological and histological evaluations. This work demonstrated the strategy of in situ injectable glue may be a potential solution for prevention of IVD degeneration. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | Ministry of Science and Technology of the People's Republic of China[2020YFA0908900];National Natural Science Foundation of China[21725403];National Natural Science Foundation of China[21935011];Shenzhen Fundamental Research Program[JCYJ20220530114409020];Science, Technology and Innovation Commission of Shenzhen Municipality[JSGG20200225151916021];Science, Technology and Innovation Commission of Shenzhen Municipality[KQTD20200820113012029];
|
| WOS Research Area | Engineering
; Materials Science
|
| WOS Subject | Engineering, Biomedical
; Materials Science, Biomaterials
|
| WOS Accession No | WOS:001050497800001
|
| Publisher | |
| Scopus EID | 2-s2.0-85166265270
|
| Data Source | Scopus
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/559576 |
| Department | Department of Biomedical Engineering |
| Affiliation | 1.Guangdong Provincial Key Laboratory of Advanced Biomaterials,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China 2.Department of Spine Surgery,The First Affiliated Hospital,Sun Yat-Sen University,Guangzhou,510275,China |
| First Author Affilication | Department of Biomedical Engineering |
| Corresponding Author Affilication | Department of Biomedical Engineering |
| First Author's First Affilication | Department of Biomedical Engineering |
| Recommended Citation GB/T 7714 |
Huang，Lin,Wang，Wantao,Xian，Yiwen,et al. Rapidly in situ forming an injectable Chitosan/PEG hydrogel for intervertebral disc repair[J]. Materials Today Bio,2023,22.
|
| APA |
Huang，Lin.,Wang，Wantao.,Xian，Yiwen.,Liu，Lei.,Fan，Jinghao.,...&Wu，Decheng.(2023).Rapidly in situ forming an injectable Chitosan/PEG hydrogel for intervertebral disc repair.Materials Today Bio,22.
|
| MLA |
Huang，Lin,et al."Rapidly in situ forming an injectable Chitosan/PEG hydrogel for intervertebral disc repair".Materials Today Bio 22(2023).
|
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