Total and Regional Fat/Muscle Mass Ratio and Risks of Incident Cardiovascular Disease and Mortality

Zhou，Rui1; Chen，Hao Wen1; Lin，Yang2; Li，Fu Rong3; Zhong，Qi1; Huang，Yi Ning1; Wu，Xian Bo1

2023-09-05

10.1161/JAHA.123.030101

Journal of the American Heart Association   Impact Factor & Quartile

2047-9980

BACKGROUND: To evaluate the sex-specific associations of total and regional fat/muscle mass ratio (FMR) with cardiovascular disease (CVD) incidence and mortality, and to explore the underlying mechanisms driven by cardiometabolites and inflammatory cells. We compared the predictive value of FMRs to body mass index. METHODS AND RESULTS: This population-based, prospective cohort study included 468 885 UK Biobank participants free of CVD at baseline. Fat mass and muscle mass were estimated using a bioelectrical impedance assessment device. FMR was calculated as fat mass divided by muscle mass in corresponding body parts (total body, trunk, arm, and leg). Multivariable Cox proportional hazards models and mediation analyses were used. During 12.5 years of follow-up, we documented 49 936 CVD cases and 4158 CVD deaths. Higher total FMR was associated with an increased risk of incident CVD (hazard ratios [HRs] were 1.63 and 1.83 for men and women, respectively), ischemic heart disease (men: HR, 1.61; women: HR, 1.81), myocardial infarction (men: HR, 1.72; women: HR, 1.49), and congestive heart failure (men: HR, 2.25; women: HR, 2.57). The positive associations of FMRs with mortality from total CVD or its subtypes were significant mainly in trunk and arm for male patients (P for trend <0.05). We also identified 8 cardiometabolites and 5 inflammatory cells that partially mediated FMR-CVD associa-tions. FMRs were modestly better at discriminating cardiovascular mortality risk. CONCLUSIONS: Higher total and regional FMRs were associated with an increased risk of CVD and mortality, partly mediated through cardiometabolites and inflammatory cells. Early monitoring of FMR should be considered to alleviate CVD risk. FMRs were superior to body mass index in predicting CVD mortality.

cardiometabolic cardiovascular disease fat/muscle ratio inflammatory mortality

SCI

English

Others

Natural Science Foundation of Guangdong Province[2021A1515011684];National Natural Science Foundation of China[82173607];

Cardiovascular System & Cardiology

Cardiac & Cardiovascular Systems

WOS:001062730000051

WILEY

2-s2.0-85169847970

Scopus

1.Department of Epidemiology,School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research),Southern Medical University,Guangzhou,China
2.Center for Disease Control and Prevention of Chaoyang District of Beijing,Beijing,China
3.School of Medicine,Southern University of Science and Technology,Shenzhen,China

Zhou，Rui,Chen，Hao Wen,Lin，Yang,et al. Total and Regional Fat/Muscle Mass Ratio and Risks of Incident Cardiovascular Disease and Mortality[J]. Journal of the American Heart Association,2023,12(17).

Zhou，Rui.,Chen，Hao Wen.,Lin，Yang.,Li，Fu Rong.,Zhong，Qi.,...&Wu，Xian Bo.(2023).Total and Regional Fat/Muscle Mass Ratio and Risks of Incident Cardiovascular Disease and Mortality.Journal of the American Heart Association,12(17).

Zhou，Rui,et al."Total and Regional Fat/Muscle Mass Ratio and Risks of Incident Cardiovascular Disease and Mortality".Journal of the American Heart Association 12.17(2023).