Patient-Derived Organoids as a Promising Tool for Multimodal Management of Sarcomas

Xu，Songfeng1,2; Tan，Shih Jye3; Guo，Ling2,3

2023-09-01

10.3390/cancers15174339

Cancers   Impact Factor & Quartile

2072-6694

The management of sarcomas, a diverse group of cancers arising from connective tissues, presents significant challenges due to their heterogeneity and limited treatment options. Patient-derived sarcoma organoids (PDSOs) have emerged as a promising tool in the multimodal management of sarcomas, offering unprecedented opportunities for personalized medicine and improved treatment strategies. This review aims to explore the potential of PDSOs as a promising tool for multimodal management of sarcomas. We discuss the establishment and characterization of PDSOs, which realistically recapitulate the complexity and heterogeneity of the original tumor, providing a platform for genetic and molecular fidelity, histological resemblance, and functional characterization. Additionally, we discuss the applications of PDSOs in pathological and genetic evaluation, treatment screening and development, and personalized multimodal management. One significant advancement of PDSOs lies in their ability to guide personalized treatment decisions, enabling clinicians to assess the response and efficacy of different therapies in a patient-specific manner. Through continued research and development, PDSOs hold the potential to revolutionize sarcoma management and drive advancements in personalized medicine, biomarker discovery, preclinical modeling, and therapy optimization. The integration of PDSOs into clinical practice can ultimately improve patient outcomes and significantly impact the field of sarcoma treatment.

patient-derived organoids personalized medicine sarcomas

SCI

English

Corresponding

Chongqing Postdoctoral Science Foundation[82273308];

Oncology

Oncology

WOS:001062407000001

MDPI

2-s2.0-85170381057

Scopus

1.National Cancer Center/National Clinical Research Center for Cancer,Cancer Hospital & Shenzhen Hospital,Chinese Academy of Medical Science,Peking Union Medical College,Shenzhen,518116,China
2.Department of Orthopedics,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital,Chinese Academy of Medical Science,Peking Union Medical College,Beijing,100021,China
3.Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Department of Biology,Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Blvd, Biology Building 402,518055,China

Xu，Songfeng,Tan，Shih Jye,Guo，Ling. Patient-Derived Organoids as a Promising Tool for Multimodal Management of Sarcomas[J]. Cancers,2023,15(17).

Xu，Songfeng,Tan，Shih Jye,&Guo，Ling.(2023).Patient-Derived Organoids as a Promising Tool for Multimodal Management of Sarcomas.Cancers,15(17).

Xu，Songfeng,et al."Patient-Derived Organoids as a Promising Tool for Multimodal Management of Sarcomas".Cancers 15.17(2023).