中文版 | English
Title

PD1 is transcriptionally regulated by LEF1 in mature T cells

Author
Corresponding AuthorZhao,Pin
Publication Years
2023-09-01
DOI
Source Title
ISSN
0171-2985
EISSN
1878-3279
Volume228Issue:5
Abstract
The role of programmed cell death 1 (PD1) in cancer immune evasion is of considerable importance, prompting the development of monoclonal antibodies that specifically target PD-1 to enhance the immune system for cancer therapy. Nevertheless, the efficacy of PD1/programmed cell death-Ligand 1 (PD-L1) blocking antibodies is limited to certain patients or tumor types. Although researchers have demonstrated the influence of PD-1 on the positive selection of T cells, its effect on the T-cell repertoire remains uncertain. Lymphoid enhancer binding factor 1 (LEF1) has been known to play a critical role as a transcription factor in the development and maturation of T cells. Despite the greater focus on the study of its homologous protein, T cell factor 1 (TCF1), we discovered that LEF1 had a positive regulatory effect on the transcription of PD1 in mature T cells, including CD4+ T cells, CD8+ T cells, and Treg cells. This finding was observed in LEF1 knockout and LEF1-stimulated mice models. Additionally, we confirmed the direct regulation of PD1 by LEF1 in tumor-infiltrating lymphocytes through tumor-implantation experiments. The direct regulation of PD1 by LEF1 was further validated in the LEF1 knockout cell line. The results of our study provide novel perspectives on the regulation of PD1 in immune responses and investigate potential approaches for clinical anti-PD1 therapy.
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URL[Source Record]
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Language
English
SUSTech Authorship
First ; Corresponding
Funding Project
Basic and Applied Basic Research Foundation of Guangdong Province[2020A1515110742];
WOS Research Area
Immunology
WOS Subject
Immunology
WOS Accession No
WOS:001050166800001
Publisher
ESI Research Field
IMMUNOLOGY
Scopus EID
2-s2.0-85166264729
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/559665
DepartmentThe Third People's Hospital of Shenzhen
Affiliation
1.National Clinical Research Center for Infectious Diseases,The Third People's Hospital of Shenzhen,Southern University of Science and Technology,Shenzhen,China
2.Department of Prevention,Health Care and Fertility,Xinfuli Community Hospital,Beijing,Linhongnong Road, Dahongmen, Fengtai District,China
3.Department of Pathogen Biology,Shenzhen University Health Science Center,Shenzhen,518055,China
First Author AffilicationThe Third People's Hospital of Shenzhen
Corresponding Author AffilicationThe Third People's Hospital of Shenzhen
First Author's First AffilicationThe Third People's Hospital of Shenzhen
Recommended Citation
GB/T 7714
Zhao,Pin,Sun,Lanming,Zhao,Cong,et al. PD1 is transcriptionally regulated by LEF1 in mature T cells[J]. Immunobiology,2023,228(5).
APA
Zhao,Pin,Sun,Lanming,Zhao,Cong,&Malik,Samiullah.(2023).PD1 is transcriptionally regulated by LEF1 in mature T cells.Immunobiology,228(5).
MLA
Zhao,Pin,et al."PD1 is transcriptionally regulated by LEF1 in mature T cells".Immunobiology 228.5(2023).
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