Electrowetting-based digital microfluidics: Toward a full-functional miniaturized platform for biochemical and biological applications

Liu，Xianming1; Ma，Dachuan1; Ye，Haiyue1,2; Hou，Yue1,2; Bai，Xue1; Xing，Yaru3; Cheng，Xing3; Lin，Bingcheng1; Lu，Yao1

2023-09-01

10.1016/j.trac.2023.117153

TrAC - Trends in Analytical Chemistry   Impact Factor & Quartile

0165-9936

1879-3142

Digital microfluidics, with a distinctive manner of droplet actuation via electrowetting on individually addressable electrodes, has made tremendous scientific and technical advances in the last twenty years or so. Its unique advantages in reduced sample consumption, programmability and reconfigurability, ease for intelligent recognition and closed-loop control on compartmentalized liquid samples, and simplicity in integrating with other technologies, offer preciseness and flexibility in discrete biological and chemical sample handling, which bring in promising application opportunities to life science studies. Meeting the growing demands in biological and biochemical applications, this accurate liquid-handling platform now moves into a stage of high-level integration and instrumentation, highlighted by miniaturization and full functionalization. In this paper, we start with a comprehension of mechanisms related to DMF technology from which novel functions of DMF devices were derived, and from a technical perspective, we provide an in-depth review of recent developments in the DMF community on new approaches in DMF chip fabrication, control and automation of DMF manipulation and system integration, instrumentation, and applications.

SCI

English

Others

National Natural Science Foundation of China[22274154];National Natural Science Foundation of China[31927802];Dalian Institute of Chemical Physics[DICP I202208];Dalian Institute of Chemical Physics[DMU-1&DICP UN202201];

Chemistry

Chemistry, Analytical

WOS:001041428200001

ELSEVIER SCI LTD

CHEMISTRY

2-s2.0-85164228144

Scopus

1.Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian,116023,China
2.Chinese Medical University,Shenyang,110122,China
3.Southern University of Science and Technology,Shenzhen,518055,China

Liu，Xianming,Ma，Dachuan,Ye，Haiyue,et al. Electrowetting-based digital microfluidics: Toward a full-functional miniaturized platform for biochemical and biological applications[J]. TrAC - Trends in Analytical Chemistry,2023,166.

Liu，Xianming.,Ma，Dachuan.,Ye，Haiyue.,Hou，Yue.,Bai，Xue.,...&Lu，Yao.(2023).Electrowetting-based digital microfluidics: Toward a full-functional miniaturized platform for biochemical and biological applications.TrAC - Trends in Analytical Chemistry,166.

Liu，Xianming,et al."Electrowetting-based digital microfluidics: Toward a full-functional miniaturized platform for biochemical and biological applications".TrAC - Trends in Analytical Chemistry 166(2023).