MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels
Piezo channels are critical cellular sensors of mechanical forces. Despite their large size, ubiquitous expression, and irreplaceable roles in an ever-growing list of physiological processes, few Piezo channel-binding proteins have emerged. In this work, we found that MyoD (myoblast determination)-family inhibitor proteins (MDFIC and MDFI) are PIEZO1/2 interacting partners. These transcriptional regulators bind to PIEZO1/2 channels, regulating channel inactivation. Using single-particle cryogenic electron microscopy, we mapped the interaction site in MDFIC to a lipidated, C-terminal helix that inserts laterally into the PIEZO1 pore module. These Piezo-interacting proteins fit all the criteria for auxiliary subunits, contribute to explaining the vastly different gating kinetics of endogenous Piezo channels observed in many cell types, and elucidate mechanisms potentially involved in human lymphatic vascular disease.
NI Journal Papers
|WOS Accession No|
|ESI Research Field|
BIOLOGY & BIOCHEMISTRY ; CLINICAL MEDICINE ; MULTIDISCIPLINARY ; PLANT & ANIMAL SCIENCE ; ENVIRONMENT/ECOLOGY ; SOCIAL SCIENCES, GENERAL ; MICROBIOLOGY ; ECONOMICS BUSINESS ; IMMUNOLOGY ; MATERIALS SCIENCE ; MATHEMATICS ; COMPUTER SCIENCE ; SPACE SCIENCE ; MOLECULAR BIOLOGY & GENETICS ; CHEMISTRY ; PSYCHIATRY/PSYCHOLOGY ; NEUROSCIENCE & BEHAVIOR ; PHYSICS ; GEOSCIENCES ; ENGINEERING
Cited Times [WOS]:2
|Document Type||Journal Article|
|Department||Department of Biomedical Engineering|
1.Victor Chang Cardiac Research Institute,Sydney,Australia
2.School of Clinical Medicine,Faculty of Medicine and Health,University of New South Wales,Sydney,NSW 2052,Australia
3.Interdisciplinary Research Center on Biology and Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,200032,China
4.State Key Laboratory of Chemical Biology,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,200032,China
5.Research School of Biology,Australian National University,Acton,2601,Australia
6.Department of Biochemistry and Molecular Biophysics,University of Chicago,Chicago,IL 60637,United States
7.Centre for Cancer Biology,University of South Australia and SA Pathology,Adelaide,SA 5001,Australia
8.Adelaide Medical School,University of Adelaide,Adelaide,
9.Department of Genetics and Molecular Pathology,SA Pathology,Adelaide,SA 5000,Australia
10.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
11.School of Biotechnology and Biomolecular Science,University of New South Wales Sydney,Kensington,NSW 2052,Australia
12.School of Biomedical Sciences,Faculty of Medicine and Health,University of New South Wales Sydney,Kensington,NSW 2052,Australia
Zhou，Zijing,Ma，Xiaonuo,Lin，Yiechang,et al. MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels[J]. Science (New York, N.Y.),2023,381(6659):799-804.
Zhou，Zijing.,Ma，Xiaonuo.,Lin，Yiechang.,Cheng，Delfine.,Bavi，Navid.,...&Cox，Charles D..(2023).MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels.Science (New York, N.Y.),381(6659),799-804.
Zhou，Zijing,et al."MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels".Science (New York, N.Y.) 381.6659(2023):799-804.
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