Aggregation-Induced Emission (AIE), Life and Health

Wang，Haoran1,2; Li，Qiyao1,3; Alam，Parvej4; Bai，Haotian5; Bhalla，Vandana6; Bryce，Martin R.7; Cao，Mingyue8; Chen，Chao2; Chen，Sijie9; Chen，Xirui10; Chen，Yuncong11; Chen，Zhijun12; Dang，Dongfeng13; Ding，Dan14; Ding，Siyang15; Duo，Yanhong16; Gao，Meng17; He，Wei2; He，Xuewen18; Hong，Xuechuan19; Hong，Yuning15; Hu，Jing Jing20; Hu，Rong21; Huang，Xiaolin10; James，Tony D.22; Jiang，Xingyu23; Konishi，Gen Ichi24; Kwok，Ryan T.K.2; Lam，Jacky W.Y.2; Li，Chunbin25; Li，Haidong26; Li，Kai27; Li，Nan28; Li，Wei Jian29; Li，Ying30; Liang，Xing Jie31,32; Liang，Yongye33; Liu，Bin34; Liu，Guozhen35; Liu，Xingang34; Lou，Xiaoding20; Lou，Xin Yue36; Luo，Liang37; McGonigal，Paul R.38; Mao，Zong Wan39; Niu，Guangle8; Owyong，Tze Cin15; Pucci，Andrea40; Qian，Jun41; Qin，Anjun3; Qiu，Zijie1; Rogach，Andrey L.42; Situ，Bo43; Tanaka，Kazuo44; Tang，Youhong45; Wang，Bingnan3; Wang，Dong46; Wang，Jianguo25; Wang，Wei29; Wang，Wen Xiong47; Wang，Wen Jin39,48; Wang，Xinyuan33; Wang，Yi Feng31,32; Wu，Shuizhu49; Wu，Yifan30; Xiong，Yonghua10; Xu，Ruohan13; Yan，Chenxu50; Yan，Saisai46; Yang，Hai Bo29; Yang，Lin Lin1; Yang，Mingwang2; Yang，Ying Wei36; Yoon，Juyoung51; Zang，Shuang Quan27; Zhang，Jiangjiang23,52; Zhang，Pengfei53; Zhang，Tianfu32; Zhang，Xin54,55; Zhang，Xin35; Zhao，Na28; Zhao，Zheng1; Zheng，Jie56; Zheng，Lei43; Zheng，Zheng57; Zhu，Ming Qiang58; Zhu，Wei Hong50; Zou，Hang43; Tang，Ben Zhong1,2

2023-08-08

10.1021/acsnano.3c03925

ACS nano   Impact Factor & Quartile

1936-0851

1936-086X

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health.

aggregation-induced emission bioimaging biomedical application combined therapy detection luminescent material monitoring phototheranostics precision medicine

SCI

English

NI Journal Papers

Others

National Natural Science Foundation of China["21871108","NSF-2107619"] ; Research Grants Council of Hong Kong[C6014-20W] ; Innovation and Technology Commission[ITC-CNERC14SC01] ; Science, Technology and Innovation Commission of Shenzhen Municipality["JCYJ2021324134613038","GJHZ20210705141810031"] ; Shenzhen Key Laboratory of Functional Aggregate Materials[ZDSYS20211021111400001] ; Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology[2019B030301003] ; China Postdoctoral Science Foundation[2022M72308] ; University of Akron[32172296] ; MEXT/JSPS KAKENHI["23H02036","17H05145"]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:001042582500001

AMER CHEMICAL SOC

2-s2.0-85167475154

Scopus

1.School of Science and Engineering,Shenzhen Institute of Aggregate Science and Technology,Chinese University of Hong Kong,Shenzhen (CUHK-Shenzhen),518172,China
2.Department of Chemistry,Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction,Division of Life Science,State Key Laboratory of Molecular Neuroscience,Guangdong-Hong Kong-Macau Joint Laboratory of Optoelectronic and Magnetic Functional Materials,Hong Kong University of Science and Technology,Kowloon,Clear Water Bay,China
3.State Key Laboratory of Luminescent Materials and Devices,Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates,South China University of Technology,Guangzhou,510640,China
4.Clinical Translational Research Center of Aggregation-Induced Emission,School of Medicine,Second Affiliated Hospital,School of Science and Engineering,Chinese University of Hong Kong,Shenzhen (CUHK- Shenzhen),518172,China
5.Beijing National Laboratory for Molecular Sciences,Key Laboratory of Organic Solids,Institute of Chemistry,Chinese Academy of Sciences,100190,China
6.Department of Chemistry,Guru Nanak Dev University,Amritsar,143005,India
7.Department of Chemistry,Durham University,Durham,South Road,DH1 3LE,United Kingdom
8.State Key Laboratory of Crystal Materials,Shandong University,Jinan,250100,China
9.Ming Wai Lau Centre for Reparative Medicine,Karolinska Institutet,China
10.State Key Laboratory of Food Science and Resources,School of Food Science and Technology,Nanchang University,Nanchang,330047,China
11.State Key Laboratory of Coordination Chemistry,School of Chemistry and Chemical Engineering,Chemistry and Biomedicine Innovation Center (ChemBIC),Department of Cardiothoracic Surgery,Nanjing Drum Tower Hospital,Medical School,Nanjing University,Nanjing,210023,China
12.Engineering Research Center of Advanced Wooden Materials and Key Laboratory of Bio-based Material Science and Technology of Ministry of Education,Northeast Forestry University,Harbin,150040,China
13.School of Chemistry,Xi'an Jiaotong University,Xi'an 710049 China,China
14.State Key Laboratory of Medicinal Chemical Biology,Key Laboratory of Bioactive Materials,Ministry of Education,College of Life Sciences,Nankai University,300071,China
15.Department of Biochemistry and Chemistry,La Trobe Institute for Molecular Science,La Trobe University,Melbourne,3086,Australia
16.Department of Radiation Oncology,Shenzhen People's Hospital (The Second Clinical Medical College,Jinan University,First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,518020,China
17.National Engineering Research Center for Tissue Restoration and Reconstruction,Key Laboratory of Biomedical Engineering of Guangdong Province,Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education,Innovation Center for Tissue Restoration and Reconstruction,School of Materials Science and Engineering,South China University of Technology,Guangzhou,510006,China
18.Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou,College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou,199 Ren'ai Road,215123,China
19.State Key Laboratory of Virology,Department of Cardiology,Zhongnan Hospital of Wuhan University,School of Pharmaceutical Sciences,Wuhan University,Wuhan,430071,China
20.State Key Laboratory of Biogeology and Environmental Geology,Engineering Research Center of Nano-Geomaterials of Ministry of Education,Faculty of Materials Science and Chemistry,China University of Geosciences,Wuhan,430074,China
21.School of Chemistry and Chemical Engineering,University of South China,Hengyang,421001,China
22.Department of Chemistry,University of Bath,Bath,BA2 7AY,United Kingdom
23.Guangdong Provincial Key Laboratory of Advanced Biomaterials,Shenzhen Key Laboratory of Smart Healthcare Engineering,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No. 1088 Xueyuan Road ,Nanshan District,518055,China
24.Department of Chemical Science and Engineering,Tokyo Institute of Technology,O-okayama ,Meguro-ku,152-8552,Japan
25.College of Chemistry and Chemical Engineering,Inner Mongolia Key Laboratory of Fine Organic Synthesis,Inner Mongolia University,Hohhot,010021,China
26.State Key Laboratory of Fine Chemicals,School of Bioengineering,Dalian University of Technology,Dalian,2 Linggong Road,116024,China
27.College of Chemistry,Zhengzhou University,Zhengzhou,100 Science Road,450001,China
28.Key Laboratory of Macromolecular Science of Shaanxi Province,Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education,School of Chemistry & Chemical Engineering,Shaanxi Normal University,Xi'an,710119,China
29.Shanghai Key Laboratory of Green Chemistry and Chemical Processes & Chang-Kung Chuang Institute,East China Normal University,3663 N. Zhongshan Road,200062,China
30.Innovation Research Center for AIE Pharmaceutical Biology,Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology,NMPA and State Key Laboratory of Respiratory Disease,School of Pharmaceutical Sciences and the Fifth Affiliated Hospital,Guangzhou Medical University,Guangzhou,511436,China
31.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology of China,100190,China
32.School of Biomedical Engineering,Guangzhou Medical University,Guangzhou,511436,China
33.Department of Materials Science and Engineering,Shenzhen Key Laboratory of Printed Organic Electronics,Southern University of Science and Technology,Shenzhen,518055,China
34.Department of Chemical and Biomolecular Engineering,National University of Singapore,4 Engineering Drive 4,117585,Singapore
35.Ciechanover Institute of Precision and Regenerative Medicine,School of Medicine,Chinese University of Hong Kong,Shenzhen (CUHK- Shenzhen),China
36.International Joint Research Laboratory of Nano-Micro Architecture Chemistry,College of Chemistry,Jilin University,Changchun,2699 Qianjin Street,130012,China
37.National Engineering Research Center for Nanomedicine,College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan,430074,China
38.Department of Chemistry,University of York,York,Heslington,YO10 5DD,United Kingdom
39.MOE Key Laboratory of Bioinorganic and Synthetic Chemistry,School of Chemistry,Sun Yat-Sen University,Guangzhou,510006,China
40.Department of Chemistry and Industrial Chemistry,University of Pisa,Pisa,Via Moruzzi 13,56124,Italy
41.State Key Laboratory of Modern Optical Instrumentations,Centre for Optical and Electromagnetic Research,College of Optical Science and Engineering,International Research Center for Advanced Photonics,Zhejiang University,Hangzhou,310058,China
42.Department of Materials Science and Engineering,City University of Hong Kong,Kowloon,China
43.Department of Laboratory Medicine,Nanfang Hospital,Southern Medical University,Guangzhou,510515,China
44.Department of Polymer Chemistry,Graduate School of Engineering,Kyoto University,Katsura ,Nishikyo-ku,615-8510,Japan
45.Institute for NanoScale Science and Technology,College of Science and Engineering,Flinders University,Bedford Park,5042,Australia
46.Center for AIE Research,College of Materials Science and Engineering,Shenzhen University,Shenzhen,518060,China
47.School of Energy and Environment and State Key Laboratory of Marine Pollution,City University of Hong Kong,Kowloon,China
48.Central Laboratory of The Second Affiliated Hospital,School of Medicine,Chinese University of Hong Kong,Longgang District People's Hospital of Shenzhen,Shenzhen (CUHK- Shenzhen),518172,China
49.State Key Laboratory of Luminescent Materials and Devices,Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates,College of Materials Science and Engineering,South China University of Technology,Guangzhou,Wushan Road 381,510640,China
50.Key Laboratory for Advanced Materials and Joint International Research,Laboratory of Precision Chemistry and Molecular Engineering,Feringa Nobel Prize Scientist Joint Research Center,Institute of Fine Chemicals,Frontiers Science Center for Materiobiology and Dynamic Chemistry,School of Chemistry and Molecular Engineering,East China University of Science and Technology,200237,China
51.Department of Chemistry and Nanoscience,Ewha Womans University,03760,South Korea
52.Key Laboratory of Molecular Medicine and Biotherapy,Ministry of Industry and Information Technology,School of Life Science,Beijing Institute of Technology,100081,China
53.Guangdong Key Laboratory of Nanomedicine,Engineering Laboratory of Nanomedicine and Nanoformulations,CAS Key Lab for Health Informatics,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,University Town of Shenzhen ,1068 Xueyuan Avenue,518055,China
54.Department of Chemistry,Research Center for Industries of the Future,Westlake University,Zhejiang Province 310030,Hangzhou,600 Dunyu Road,China
55.Westlake Laboratory of Life Sciences and Biomedicine,Zhejiang Province 310024,Hangzhou,18 Shilongshan Road,China
56.Department of Chemical,Biomolecular,Corrosion Engineering The University of Akron,Akron,44325,United States
57.School of Chemistry and Chemical Engineering,Hefei University of Technology,Hefei,230009,China
58.Wuhan National Laboratory for Optoelectronics,School of Optical and Electronic Information,Huazhong University of Science and Technology,Wuhan,430074,China

Wang，Haoran,Li，Qiyao,Alam，Parvej,et al. Aggregation-Induced Emission (AIE), Life and Health[J]. ACS nano,2023,17(15):14347-14405.

Wang，Haoran.,Li，Qiyao.,Alam，Parvej.,Bai，Haotian.,Bhalla，Vandana.,...&Tang，Ben Zhong.(2023).Aggregation-Induced Emission (AIE), Life and Health.ACS nano,17(15),14347-14405.

Wang，Haoran,et al."Aggregation-Induced Emission (AIE), Life and Health".ACS nano 17.15(2023):14347-14405.