Effect of DHCR7 for the co-occurrence of hypercholesterolemia and vitamin D deficiency in type 2 diabetes: Perspective of health prevention

Sun，Lijie1; Lu，Jixuan1; Yao，Dengju2; Li，Xinyu1; Cao，Yan1; Gao，Jie1; Liu，Jiangwen3; Zheng，Tiansheng3; Wang，Huihui4; Zhan，Xiaorong1,3

2023-08-01

10.1016/j.ypmed.2023.107576

Preventive Medicine   Impact Factor & Quartile

0091-7435

1096-0260

Type 2 diabetes mellitus (T2DM) is a complex disease caused by multiple factors, which are often accompanied by the disorder of glucose and lipid metabolism and the lack of vitamin D.Over the years, researchers have conducted numerous studies into the pathogenesis and prevention strategies of diabetes. In this study, diabetic SD rats were randomly divided into type 2 diabetes group, vitamin D intervention group, 7-dehydrocholesterole reductase (DHCR7) inhibitor intervention group, simvastatin intervention group, and naive control group. Before and 12 weeks after intervention, liver tissue was extracted to isolate hepatocytes. Compared with naive control group, in the type 2 diabetic group without interference, the expression of DHCR7 increased, the level of 25(OH)D decreased, the level of cholesterol increased. In the primary cultured naive and type 2 diabetic hepatocytes, the expression of genes related to lipid metabolism and vitamin D metabolism were differently regulated in each of the 5 treatment groups. Overall, DHCR7 is an indicator for type 2 diabetic glycolipid metabolism disorder and vitamin D deficiency. Targeting DHCR7 will help with T2DM therapy.The management model of comprehensive health intervention can timely discover the disease problems of diabetes patients and high-risk groups and reduce the incidence of diabetes.

7-dehydrocholesterol reductase Expression of genes Glycolipid metabolism disorder Type 2 diabetes mellitus Vitamin D deficiency

SCI

English

Corresponding

National Natural Science Foundation of China[62172128];

Public, Environmental & Occupational Health ; General & Internal Medicine

Public, Environmental & Occupational Health ; Medicine, General & Internal

WOS:001035714700001

ACADEMIC PRESS INC ELSEVIER SCIENCE

SOCIAL SCIENCES, GENERAL

2-s2.0-85162162569

Scopus

1.Department of Endocrinology,First Affiliated Hospital of Harbin Medical University,Harbin,China
2.School of Computer Science and Technology,Harbin University of Science and Technology,Harbin,China
3.Department of Endocrinology,Southern University of Science and Technology Hospital,Shenzhen,China
4.Department of Endocrinology,Qiqihar First Hospital,Qiqihar,China

Sun，Lijie,Lu，Jixuan,Yao，Dengju,et al. Effect of DHCR7 for the co-occurrence of hypercholesterolemia and vitamin D deficiency in type 2 diabetes: Perspective of health prevention[J]. Preventive Medicine,2023,173.

Sun，Lijie.,Lu，Jixuan.,Yao，Dengju.,Li，Xinyu.,Cao，Yan.,...&Zhan，Xiaorong.(2023).Effect of DHCR7 for the co-occurrence of hypercholesterolemia and vitamin D deficiency in type 2 diabetes: Perspective of health prevention.Preventive Medicine,173.

Sun，Lijie,et al."Effect of DHCR7 for the co-occurrence of hypercholesterolemia and vitamin D deficiency in type 2 diabetes: Perspective of health prevention".Preventive Medicine 173(2023).