COVID-19 Metabolomic-Guided Amino Acid Therapy Protects from Inflammation and Disease Sequelae

Ming，Siqi1,2; Qu，Siying1; Wu，Yongjian1; Wei，Jiayou1; Zhang，Guoliang2; Jiang，Guanmin1; Huang，Xi1,2

2023-08-01

10.1002/adbi.202200265

Advanced Biology   Impact Factor & Quartile

2701-0198

The outbreak of coronavirus disease 2019 (COVID-19) has caused a worldwide pandemic since 2019. A metabolic disorder is a contributing factor to deaths from COVID-19. However, the underlying mechanism of metabolic dysfunction in COVID-19 patients and the potential interventions are not elucidated. Here targeted plasma metabolomic is performed, and the metabolite profiles among healthy controls, and asymptomatic, moderate, and severe COVID-19 patients are compared. Among the altered metabolites, arachidonic acid and linolenic acid pathway metabolites are profoundly up-regulated in COVID-19 patients. Arginine biosynthesis, alanine, aspartate, and glutamate metabolism pathways are significantly disturbed in asymptomatic patients. In the comparison of metabolite variances among the groups, higher levels of l-citrulline and l-glutamine are found in asymptomatic carriers and moderate or severe patients at the remission stage. Furthermore, l-citrulline and l-glutamine combination therapy is demonstrated to effectively protect mice from coronavirus infection and endotoxin-induced sepsis, and is observed to efficiently prevent the occurrence of pulmonary fibrosis and central nervous system damage. Collectively, the data reveal the metabolite profile of asymptomatic COVID-19 patients and propose a potential strategy for COVID-19 treatment.

asymptomatic patients coronavirus disease 2019 l-citrulline l-glutamine metabolomic

SCI

English

Corresponding

National Natural Science Foundation of China[82072062];National Natural Science Foundation of China[82102249];

WOS:000932758300001

2-s2.0-85148039772

Scopus

1.Center for Infection and Immunity and Guangdong Provincial Key Laboratory of Biomedical Imaging,The Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,Guangdong Province,519000,China
2.National Clinical Research Center for Infectious Diseases,Shenzhen Third People's Hospital,Southern University of Science and Technology,Shenzhen,Guangdong Province,518100,China

Ming，Siqi,Qu，Siying,Wu，Yongjian,et al. COVID-19 Metabolomic-Guided Amino Acid Therapy Protects from Inflammation and Disease Sequelae[J]. Advanced Biology,2023,7(8).

Ming，Siqi.,Qu，Siying.,Wu，Yongjian.,Wei，Jiayou.,Zhang，Guoliang.,...&Huang，Xi.(2023).COVID-19 Metabolomic-Guided Amino Acid Therapy Protects from Inflammation and Disease Sequelae.Advanced Biology,7(8).

Ming，Siqi,et al."COVID-19 Metabolomic-Guided Amino Acid Therapy Protects from Inflammation and Disease Sequelae".Advanced Biology 7.8(2023).