COVID-19 Metabolomic-Guided Amino Acid Therapy Protects from Inflammation and Disease Sequelae
|Corresponding Author||Zhang，Guoliang; Jiang，Guanmin; Huang，Xi|
The outbreak of coronavirus disease 2019 (COVID-19) has caused a worldwide pandemic since 2019. A metabolic disorder is a contributing factor to deaths from COVID-19. However, the underlying mechanism of metabolic dysfunction in COVID-19 patients and the potential interventions are not elucidated. Here targeted plasma metabolomic is performed, and the metabolite profiles among healthy controls, and asymptomatic, moderate, and severe COVID-19 patients are compared. Among the altered metabolites, arachidonic acid and linolenic acid pathway metabolites are profoundly up-regulated in COVID-19 patients. Arginine biosynthesis, alanine, aspartate, and glutamate metabolism pathways are significantly disturbed in asymptomatic patients. In the comparison of metabolite variances among the groups, higher levels of l-citrulline and l-glutamine are found in asymptomatic carriers and moderate or severe patients at the remission stage. Furthermore, l-citrulline and l-glutamine combination therapy is demonstrated to effectively protect mice from coronavirus infection and endotoxin-induced sepsis, and is observed to efficiently prevent the occurrence of pulmonary fibrosis and central nervous system damage. Collectively, the data reveal the metabolite profile of asymptomatic COVID-19 patients and propose a potential strategy for COVID-19 treatment.
National Natural Science Foundation of China;National Natural Science Foundation of China;
|WOS Accession No|
Cited Times [WOS]:0
|Document Type||Journal Article|
|Department||The Third People's Hospital of Shenzhen|
1.Center for Infection and Immunity and Guangdong Provincial Key Laboratory of Biomedical Imaging,The Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,Guangdong Province,519000,China
2.National Clinical Research Center for Infectious Diseases,Shenzhen Third People's Hospital,Southern University of Science and Technology,Shenzhen,Guangdong Province,518100,China
|First Author Affilication||The Third People's Hospital of Shenzhen|
|Corresponding Author Affilication||The Third People's Hospital of Shenzhen|
Ming，Siqi,Qu，Siying,Wu，Yongjian,et al. COVID-19 Metabolomic-Guided Amino Acid Therapy Protects from Inflammation and Disease Sequelae[J]. Advanced Biology,2023,7(8).
Ming，Siqi.,Qu，Siying.,Wu，Yongjian.,Wei，Jiayou.,Zhang，Guoliang.,...&Huang，Xi.(2023).COVID-19 Metabolomic-Guided Amino Acid Therapy Protects from Inflammation and Disease Sequelae.Advanced Biology,7(8).
Ming，Siqi,et al."COVID-19 Metabolomic-Guided Amino Acid Therapy Protects from Inflammation and Disease Sequelae".Advanced Biology 7.8(2023).
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