Controlling NIR-II emitting gold organic/inorganic nanohybrids with tunable morphology and surface PEG density for dynamic visualization of vascular dysfunction
Luminescent Au nanoparticles (AuNPs) and their organic/inorganic nanohybrids are of interest due to their favorable properties and promising biomedical applications. However, most existing AuNP-based hybrid nanostructures cannot satisfy high efficiency in synthesis, deep tissue penetration, and long blood circulation simultaneously, thus cannot be employed in dynamic monitoring of biomedical applications. In this paper, using Pluronic F127 as a template, we report a robust approach for one-pot synthesis of AuNP-based organic/inorganic nanohybrids (AuNHs) with bright luminescence in the second near-infrared (NIR-II) window, tunable shape, and controllable surface polyethylene glycol (PEG) density. The nanohybrids could be controlled from a necklace-like shape with a dense brush PEG configuration to a spherical structure with a brush PEG coating, which greatly impacts the in vivo biological behavior. Compared to spherical AuNHs, the necklace-shaped AuNHs present a higher quantum yield and longer blood circulation, which are superior to most of the individual AuNPs. With these outstanding features, the necklace-shaped AuNHs could achieve real-time, dynamic visualization of vascular dysfunction, capable of directing the precise administration of thrombolytics (a medicine for the breakdown of blood clots). These findings could provide a powerful guide for designing novel NIR-II nanoprobes toward in vivo dynamic information visualization.
NI Journal Papers ; NI论文
First ; Corresponding
National Key Research and Development Program of China["2021YFF1200100","2018YFA0902600","2020YFA0908900","2021YFF1200800"] ; National Natural Science Foundation of China["21907032","81730051","22234004","32071390"] ; Shenzhen Science and Technology Program["KQTD20190929172743294","JCYJ20200109141231365"] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003] ; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009] ; Guangdong Innovative and Entrepreneurial Research Team Program[2019ZT08Y191] ; Guangdong Major Talent Introduction Project[2019CX01Y196]
|WOS Research Area|
|WOS Accession No|
Cited Times [WOS]:0
|Document Type||Journal Article|
|Department||Department of Biomedical Engineering|
1.Shenzhen Key Laboratory of Smart Healthcare Engineering,Guangdong Provincial Key Laboratory of Advanced Biomaterials,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No. 1088 Xueyuan Rd, Nanshan District, Guangdong,518055,China
2.Institute for Advanced Study,Shenzhen University,Shenzhen,No. 3688 Nanhai Avenue, Nanshan District, Guangdong,518060,China
|First Author Affilication||Department of Biomedical Engineering|
|Corresponding Author Affilication||Department of Biomedical Engineering|
|First Author's First Affilication||Department of Biomedical Engineering|
Zhou，Tingyao,Zha，Menglei,Tang，Hao,et al. Controlling NIR-II emitting gold organic/inorganic nanohybrids with tunable morphology and surface PEG density for dynamic visualization of vascular dysfunction[J]. Chemical Science,2023,14(33):8842-8849.
Zhou，Tingyao,Zha，Menglei,Tang，Hao,Li，Kai,&Jiang，Xingyu.(2023).Controlling NIR-II emitting gold organic/inorganic nanohybrids with tunable morphology and surface PEG density for dynamic visualization of vascular dysfunction.Chemical Science,14(33),8842-8849.
Zhou，Tingyao,et al."Controlling NIR-II emitting gold organic/inorganic nanohybrids with tunable morphology and surface PEG density for dynamic visualization of vascular dysfunction".Chemical Science 14.33(2023):8842-8849.
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