| Title | O-GlcNAcylation promotes topoisomerase IIα catalytic activity in breast cancer chemoresistance |
| Author | |
| Corresponding Author | Wu，Sijin; Zhang，Jianing; Liu，Yubo |
| Publication Years | 2023-07-05
|
| DOI | |
| Source Title | |
| ISSN | 1469-221X
|
| EISSN | 1469-3178
|
| Volume | 24Issue:7 |
| Abstract | DNA topoisomerase IIα (TOP2A) plays a vital role in replication and cell division by catalytically altering DNA topology. It is a prominent target for anticancer drugs, but clinical efficacy is often compromised due to chemoresistance. In this study, we investigate the role of TOP2A O-GlcNAcylation in breast cancer cells and patient tumor tissues. Our results demonstrate that elevated TOP2A, especially its O-GlcNAcylation, promotes breast cancer malignant progression and resistance to adriamycin (Adm). O-GlcNAcylation at Ser1469 enhances TOP2A chromatin DNA binding and catalytic activity, leading to resistance to Adm in breast cancer cells and xenograft models. Mechanistically, O-GlcNAcylation-modulated interactions between TOP2A and cell cycle regulators influence downstream gene expression and contribute to breast cancer drug resistance. These results reveal a previously unrecognized mechanistic role for TOP2A O-GlcNAcylation in breast cancer chemotherapy resistance and provide support for targeting TOP2A O-GlcNAcylation in cancer therapy. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Others
|
| Funding Project | National Natural Science Foundation of China[32171282];Fundamental Research Funds for the Central Universities[DUT22YG131];
|
| WOS Research Area | Biochemistry & Molecular Biology
; Cell Biology
|
| WOS Subject | Biochemistry & Molecular Biology
; Cell Biology
|
| WOS Accession No | WOS:000997031600001
|
| Publisher | |
| ESI Research Field | MOLECULAR BIOLOGY & GENETICS
|
| Scopus EID | 2-s2.0-85161590322
|
| Data Source | Scopus
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/559857 |
| Department | Department of Chemistry 理学院 |
| Affiliation | 1.School of Life and Pharmaceutical Sciences,Dalian University of Technology,Panjin,China 2.Department of Chemistry,College of Science,Southern University of Science and Technology,Shenzhen,China 3.Blood Diseases Institute,Xuzhou Medical University,Xuzhou,Jiangsu,China 4.Department of Chemistry,The University of Hong Kong,Hong Kong 5.Laboratory for Synthetic Chemistry and Chemical Biology Limited,Hong Kong Science Park,Hong Kong 6.Department of Oncology,The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University,Huai'an,China 7.Laboratory of Molecular Modeling and Design,State Key Laboratory of Molecular Reaction Dynamics,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian,China |
| Recommended Citation GB/T 7714 |
Liu，Yangzhi,Yu，Kairan,Zhang，Keren,et al. O-GlcNAcylation promotes topoisomerase IIα catalytic activity in breast cancer chemoresistance[J]. EMBO Reports,2023,24(7).
|
| APA |
Liu，Yangzhi.,Yu，Kairan.,Zhang，Keren.,Niu，Mingshan.,Chen，Qiushi.,...&Liu，Yubo.(2023).O-GlcNAcylation promotes topoisomerase IIα catalytic activity in breast cancer chemoresistance.EMBO Reports,24(7).
|
| MLA |
Liu，Yangzhi,et al."O-GlcNAcylation promotes topoisomerase IIα catalytic activity in breast cancer chemoresistance".EMBO Reports 24.7(2023).
|
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