Temporal dynamics of electroencephalographic microstates during sustained pain

Qiu，Shuang1,2; Lyu，Xiaohan3; Zheng，Qianqian3; He，Huiguang1,2; Jin，Richu4; Peng，Weiwei3

2023-07-01

10.1093/cercor/bhad143

Cerebral Cortex   Impact Factor & Quartile

1047-3211

1460-2199

Brain dynamics can be modeled by a sequence of transient, nonoverlapping patterns of quasi-stable electrical potentials named "microstates."While electroencephalographic (EEG) microstates among patients with chronic pain remained inconsistent in the literature, this study characterizes the temporal dynamics of EEG microstates among healthy individuals during experimental sustained pain. We applied capsaicin (pain condition) or control (no-pain condition) cream to 58 healthy participants in different sessions and recorded resting-state EEG 15 min after application. We identified 4 canonical microstates (A-D) that are related to auditory, visual, salience, and attentional networks. Microstate C had less occurrence, as were bidirectional transitions between microstate C and microstates A and B during sustained pain. In contrast, sustained pain was associated with more frequent and longer duration of microsite D, as well as more bidirectional transitions between microstate D and microstates A and B. Microstate D duration positively correlated with intensity of ongoing pain. Sustained pain improved global integration within microstate C functional network, but weakened global integration and efficiency within microstate D functional network. These results suggest that sustained pain leads to an imbalance between processes that load on saliency (microstate C) and processes related to switching and reorientation of attention (microstate D).

electroencephalogram functional network topology microstate analysis resting-state network sustained pain

SCI

English

Corresponding

National Natural Science Foundation of China["32271105","62101236","62276262"] ; Shenzhen Basic Research Project[JCYJ20190 808154413592] ; Beijing Natural Science Foundation[7222311]

Neurosciences & Neurology

Neurosciences

WOS:000977725000001

OXFORD UNIV PRESS INC

NEUROSCIENCE & BEHAVIOR

2-s2.0-85165613944

Scopus

1.Laboratory of Brain Atlas and Brain-Inspired Intelligence,State Key Laboratory of Multimodal Artificial Intelligence Systems,Institute of Automation,Chinese Academy of Science,Beijing,100190,China
2.School of Artificial Intelligence,University of Chinese Academy of Sciences,Beijing,100049,China
3.School of Psychology,Shenzhen University,Shenzhen,Guangdong,518060,China
4.Department of Computer Science and Engineering,Southern University of Science and Technology,Shenzhen,XueyuanAve1088, , Guangdong,518055,China

Qiu，Shuang,Lyu，Xiaohan,Zheng，Qianqian,et al. Temporal dynamics of electroencephalographic microstates during sustained pain[J]. Cerebral Cortex,2023,33(13):8594-8604.

Qiu，Shuang,Lyu，Xiaohan,Zheng，Qianqian,He，Huiguang,Jin，Richu,&Peng，Weiwei.(2023).Temporal dynamics of electroencephalographic microstates during sustained pain.Cerebral Cortex,33(13),8594-8604.

Qiu，Shuang,et al."Temporal dynamics of electroencephalographic microstates during sustained pain".Cerebral Cortex 33.13(2023):8594-8604.