Autocorrelation analysis-based OCT velocimetry for axial blood flow velocity imaging of the cerebral capillary network

Guo，Xiangsen; Ren，Guangyuan; Tang，Jianbo

2023-07-01

10.1364/OL.493011

Cancer Research   Impact Factor & Quartile

0008-5472

1538-7445

The accurate measurement of blood flow velocity in the capillary network is challenging due to the small size of the vessels and the slow flow of red blood cells (RBCs) within the vessel. Here, we introduce an autocorrelation analysis-based optical coherence tomography (OCT) method that takes less acquisition time to measure the axial blood flow velocity in the capillary network. The axial blood flow velocity was obtained from the phase change in the decorrelation period of the first-order field autocorrelation function (g) of the OCT field data, which was acquired with M-mode acquisition (repeated A-scans). The rotation center of g in the complex plane was first re-centralized to the origin, then the phase change due to the movement of RBCs was extracted in the g decorrelation period which is usually 0.2–0.5 ms. In phantom experiments, the results suggest that the proposed method could accurately measure the axial speed with a wide range of 0.5–15 mm/s. We further tested the method on living animals. Compared with the phase-resolved Doppler optical coherence tomography (pr-DOCT), the proposed method can obtain robust axial velocity measurements with more than five times shorter acquisition time.

SCI

English

NI Journal Papers

First ; Corresponding

Shenzhen Graduate School, Peking University[1406001];Shenzhen Graduate School, Peking University[2021031616];Guangdong Science and Technology Department[2022A151];Guangdong Provincial Key Laboratory of Urology[2022B1212010003];Guangdong Science and Technology Department[5011984];National Natural Science Foundation of China[62220106006];National Natural Science Foundation of China[62275116];

Optics

Optics

WOS:001033631600002

Optica Publishing Group

CLINICAL MEDICINE

2-s2.0-85164234158

Scopus

Guangdongs Provincial Key Laboratory of Advanced Biomaterials,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China

Guo，Xiangsen,Ren，Guangyuan,Tang，Jianbo. Autocorrelation analysis-based OCT velocimetry for axial blood flow velocity imaging of the cerebral capillary network[J]. Cancer Research,2023,48(13):3599-3602.

Guo，Xiangsen,Ren，Guangyuan,&Tang，Jianbo.(2023).Autocorrelation analysis-based OCT velocimetry for axial blood flow velocity imaging of the cerebral capillary network.Cancer Research,48(13),3599-3602.

Guo，Xiangsen,et al."Autocorrelation analysis-based OCT velocimetry for axial blood flow velocity imaging of the cerebral capillary network".Cancer Research 48.13(2023):3599-3602.