Selenium supplementation provides potent neuroprotection following cerebral ischemia in mice
|Corresponding Author||Walker，Tara L.; Hou，Sheng Tao|
Despite progress in reperfusion therapy, functional recovery remains suboptimal in many stroke patients, with oxidative stress, inflammation, dysbiosis, and secondary neurodegeneration constituting the major hurdles to recovery. The essential trace element selenium is emerging as a promising therapeutic agent for stroke. However, although several rodent studies have shown that selenium can protect against cell loss following cerebral ischemia, no study has yet examined whether selenium can enhance long-term functional recovery. Moreover, published studies have typically reported a single mechanism of action underlying selenium-mediated stroke recovery. However, we propose that selenium is more likely to have multifaceted actions. Here, we show that selenomethionine confers a potent neuroprotective effect in a canonical filament-induced transient middle cerebral artery occlusion (tMCAO) mouse model. Post-tMCAO selenium treatment significantly reduces the cerebral infarct volume, oxidative stress, and ferroptosis and enhances post-tMCAO motor performance in the acute phase after stroke. Moreover, analysis of the gut microbiota reveals that acute selenium treatment reverses stroke-induced gut dysbiosis. Longer-term selenium supplementation activates intrinsic neuroprotective mechanisms, prevents secondary neurodegeneration, alleviates systemic inflammation, and diminishes gut microbe-derived circulating trimethylamine N-oxide. These findings demonstrate that selenium treatment even after cerebral ischemia has long-term and multifaceted neuroprotective effects, highlighting its clinical potential.
First ; Corresponding
National Natural Science Foundation of China ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions["2021SHIBS0002","2022HIBS0002"] ; Shenzhen Science and Technology Innovation Committee[JCYJ20180504165806229]
|WOS Research Area|
Endocrinology & Metabolism ; Hematology ; Neurosciences & Neurology
Endocrinology & Metabolism ; Hematology ; Neurosciences
|WOS Accession No|
|ESI Research Field|
NEUROSCIENCE & BEHAVIOR
Cited Times [WOS]:0
|Document Type||Journal Article|
|Department||Department of Biology|
1.Brain Research Centre,Department of Biology,School of Life Science,Southern University of Science and Technology,Shenzhen,China
2.Queensland Brain Institute,The University of Queensland,Brisbane,Australia
3.Hearing Research Group,Department of Anatomy and Neurobiology,College of Medicine,Northeast Ohio Medical University,Rootstown,United States
|First Author Affilication||Department of Biology; School of Life Sciences|
|Corresponding Author Affilication||Department of Biology; School of Life Sciences|
|First Author's First Affilication||Department of Biology; School of Life Sciences|
Zhuo，Zhan,Wang，Huimei,Zhang，Shuai,et al. Selenium supplementation provides potent neuroprotection following cerebral ischemia in mice[J]. Journal of Cerebral Blood Flow and Metabolism,2023,43(7):1060-1076.
Zhuo，Zhan,Wang，Huimei,Zhang，Shuai,Bartlett，Perry F.,Walker，Tara L.,&Hou，Sheng Tao.(2023).Selenium supplementation provides potent neuroprotection following cerebral ischemia in mice.Journal of Cerebral Blood Flow and Metabolism,43(7),1060-1076.
Zhuo，Zhan,et al."Selenium supplementation provides potent neuroprotection following cerebral ischemia in mice".Journal of Cerebral Blood Flow and Metabolism 43.7(2023):1060-1076.
|Files in This Item:||There are no files associated with this item.|
|Recommend this item|
|Export to Endnote|
|Export to Excel|
|Export to Csv|
|Similar articles in Google Scholar|
|Similar articles in Baidu Scholar|
|Similar articles in Bing Scholar|
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.