Chromium Nanoparticles Improve Macrophage and T Cell Infiltration for Cancer Immunotherapy
|Corresponding Author||Luo，Dixian; Rao，Lang|
Immune checkpoint blockade has been regarded as a highly promising cancer immunotherapy approach. However, inefficient immune cell infiltration and the immunosuppressive tumor microenvironment (TME) remain significant causes of low clinical response rates. Here, we identified that trivalent chromium irons (Cr) could enhance tumor infiltration of immune cells including M1-type tumor-associated macrophages and CD8 T cells. Mechanistically, this effect is dependent on the expression of macrophage inflammatory protein-1α (MIP-1α) and the PI3K/Akt/mTOR pathway. Moreover, the Cr-based nanoparticles (Cr NPs) exhibited superior photothermal properties under near-infrared laser irradiation, showing great potential in transforming “cold” tumors into “hot” ones. In combination with the PD-1/PD-L1 pathway inhibitor, we demonstrated that the Cr NPs significantly improved anticancer efficacy in mouse models of hepatoma and melanoma by increasing antitumor immune cell infiltration and relieving immunosuppressive TME. Overall, the Cr NPs offer a new dual-functional platform for local and systemic cancer treatments, paving the way toward cancer photometalloimmunotherapy.
National Natural Science Foundation of China["82272779","82273236","82222035","82003036"] ; Guangdong Basic and Applied Basic Research Foundation["2021A1515220059","2021A1515111036","2022A1515110308","2023A1515030182"] ; Science and Technology Innovation Commission of Shenzhen["JCYJ20190806160412946","JCYJ20220530141608020"] ; Shenzhen Bay Laboratory Startup Fund
|WOS Research Area|
Materials Science, Multidisciplinary
|WOS Accession No|
Cited Times [WOS]:0
|Document Type||Journal Article|
|Department||Shenzhen People's Hospital|
1.Division of Hepatobiliary and Pancreas Surgery,Department of General Surgery,Shenzhen People’s Hospital,(The Second Clinical Medical College,Jinan University,and The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,518020,China
2.Institute of Biomedical Health Technology and Engineering,Shenzhen Bay Laboratory,Shenzhen,518132,China
3.Department of Laboratory Medicine,Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital),Shenzhen University,Shenzhen,518052,China
4.Department of Microbiology,Tumor and Cell Biology (MTC),Karolinska Institutet,Stockholm,17177,Sweden
5.Department of Interventional Radiology,Shenzhen People’s Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,518020,China
|First Author Affilication||Shenzhen People's Hospital|
|First Author's First Affilication||Shenzhen People's Hospital|
Liu，Quan,Sun，Zhe,Duo，Yanhong,et al. Chromium Nanoparticles Improve Macrophage and T Cell Infiltration for Cancer Immunotherapy[J]. ACS Materials Letters,2023,5(6):1738-1751.
Liu，Quan.,Sun，Zhe.,Duo，Yanhong.,Yin，Lei.,Lv，Kongpeng.,...&Rao，Lang.(2023).Chromium Nanoparticles Improve Macrophage and T Cell Infiltration for Cancer Immunotherapy.ACS Materials Letters,5(6),1738-1751.
Liu，Quan,et al."Chromium Nanoparticles Improve Macrophage and T Cell Infiltration for Cancer Immunotherapy".ACS Materials Letters 5.6(2023):1738-1751.
|Files in This Item:||There are no files associated with this item.|
|Recommend this item|
|Export to Endnote|
|Export to Excel|
|Export to Csv|
|Similar articles in Google Scholar|
|Similar articles in Baidu Scholar|
|Similar articles in Bing Scholar|
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.