中文版 | English
Title

Impact of some antiviral drugs on health care utilization for patients with COVID-19: a systematic review and meta-analysis

Author
Corresponding AuthorZhu,Bin
Publication Years
2023
DOI
Source Title
ISSN
1478-7210
EISSN
1744-8336
Volume21Issue:9Pages:993-1009
Abstract
Background: We aimed to assess the impact of antiviral drugs (fluvoxamine,remdesivir, lopinavir/ritonavir (LPV/r), molnupiravir, andnirmatrelvir/ritonavir (NRV/r)) on health care utilization (HCU) inCOVID-19 patients. We summarized findings from randomized controlledtrials (RCTs) and observational studies. Methods: We systematically searched four medical databases (PubMed, Web of Science, Embase, Cochrane Library) for COVID-19 studies up to February 15, 2023. A comprehensive review, meta-analysis, sensitivity analysis, and subgroup analysis were conducted. Pooled effects with 95% confidence intervals (CIs) were calculated for antiviral drugs' impact on hospitalization, mechanical ventilation (MV), and intensive care unit (ICU) outcomes. Results: Our analysis included 34 studies (584,978 patients). Meta-analysisindicated potential benefits: remdesivir and molnupiravir potentiallyreduced MV risk, and NRV/r correlated with lower hospitalizationrates. However, LPV/r did not notably curb HCU. Remdesivir waspreferable for high-risk COVID-19 patients, while molnupiravir andNRV/r were recommended for those aged 60 and above. Conclusion: Remdesivir, molnupiravir, and NRV/r may reduce HCU during the COVID-19 pandemic. However, due to limited study details and significant heterogeneity in effect estimates, further precise evidence is crucial, especially concerning emerging variants.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
First ; Corresponding
WOS Research Area
Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
WOS Subject
Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
WOS Accession No
WOS:001058849400001
Publisher
Scopus EID
2-s2.0-85169807893
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/560069
DepartmentSchool of Public Health and Emergency Management
Affiliation
1.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,China
2.Shenzhen Health Development Research and Data Management Center,Shenzhen,China
3.Vanke School of Public Health,Tsinghua University,Beijing,China
4.China Institute for Urban Governance,Shanghai Jiao Tong University,Shanghai,China
5.School of International and Public Affairs,Shanghai Jiao Tong University,Shanghai,China
6.Stanford Center on China's Economy and Institutions,Stanford University,Stanford,United States
7.School of Public Policy and Administration,Northwestern Polytechnical University,Xi’an,China
First Author AffilicationSchool of Public Health and Emergency Management
Corresponding Author AffilicationSchool of Public Health and Emergency Management
First Author's First AffilicationSchool of Public Health and Emergency Management
Recommended Citation
GB/T 7714
Wei,Bincai,Zhang,Ruhao,Zeng,Huatang,et al. Impact of some antiviral drugs on health care utilization for patients with COVID-19: a systematic review and meta-analysis[J]. Expert Review of Anti-Infective Therapy,2023,21(9):993-1009.
APA
Wei,Bincai.,Zhang,Ruhao.,Zeng,Huatang.,Wu,Liqun.,He,Rongxin.,...&Zhu,Bin.(2023).Impact of some antiviral drugs on health care utilization for patients with COVID-19: a systematic review and meta-analysis.Expert Review of Anti-Infective Therapy,21(9),993-1009.
MLA
Wei,Bincai,et al."Impact of some antiviral drugs on health care utilization for patients with COVID-19: a systematic review and meta-analysis".Expert Review of Anti-Infective Therapy 21.9(2023):993-1009.
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