A Supramolecular Naphthalene Diimide Radical Anion with Efficient NIR-II Photothermal Conversion for E. coli-Responsive Photothermal Therapy

Hu，Hao1; Zhang，Yang Yang1,2; Ma，He1; Yang，Yuchong1; Mei，Shan1; Li，Jun1,2; Xu，Jiang Fei1; Zhang，Xi1

2023

10.1002/anie.202308513

Angewandte Chemie - International Edition   Impact Factor & Quartile

1433-7851

1521-3773

We report a supramolecular naphthalene diimide (NDI) radical anion with efficient NIR-II photothermal conversion for E. coli-responsive photothermal therapy. The supramolecular radical anion (NDI-2CB[7])⋅, which is obtained from the E. coli-induced in situ reduction of NDI-2CB[7] neutral complex, formed by the host–guest interaction between an NDI derivative and cucurbit[7]uril (CB[7]), exhibits unexpectedly strong NIR-II absorption and remarkable photothermal conversion capacity in aqueous solution. The NIR-II absorption is caused by the self-assembly of NDI radical anions to form supramolecular dimer radicals in aqueous solution, which is supported by theoretically predicted spectra. The (NDI-2CB[7])⋅ demonstrates excellent NIR-II photothermal antimicrobial activity (>99 %). This work provides a new approach for constructing NIR-II photothermal agents and non-contact treatments for bacterial infections.

Antibacterial Host-Guest Systems Photochemistry Photothermal Therapy Supramolecular Chemistry

SCI

English

NI Journal Papers

Others

This work was financially supported by the Ministry of Science and Technology of China (2018YFA0208900, 2022YFA1503900, 2022YFA1503000), the National Natural Science Foundation of China (21821001, 22033005), and the Strategic Priority Research Program of C["2022YFA1503900","2022YFA1503000","21821001"] ; Ministry of Science and Technology of China["22033005","XDB36000000"] ; National Natural Science Foundation of China[2020B121201002] ; null[2018YFA0208900]

Chemistry

Chemistry, Multidisciplinary

WOS:001061067900001

WILEY-V C H VERLAG GMBH

CHEMISTRY

2-s2.0-85169414266

Scopus

1.Key Lab of Organic Optoelectronics & Molecular Engineering of Ministry of Education,Engineering Research Center of Advanced Rare-Earth Materials of Ministry of Education,Department of Chemistry,Tsinghua University,Beijing,100084,China
2.Department of Chemistry,Southern University of Science and Technology,Shenzhen,518005,China

Hu，Hao,Zhang，Yang Yang,Ma，He,et al. A Supramolecular Naphthalene Diimide Radical Anion with Efficient NIR-II Photothermal Conversion for E. coli-Responsive Photothermal Therapy[J]. Angewandte Chemie - International Edition,2023.

Hu，Hao.,Zhang，Yang Yang.,Ma，He.,Yang，Yuchong.,Mei，Shan.,...&Zhang，Xi.(2023).A Supramolecular Naphthalene Diimide Radical Anion with Efficient NIR-II Photothermal Conversion for E. coli-Responsive Photothermal Therapy.Angewandte Chemie - International Edition.

Hu，Hao,et al."A Supramolecular Naphthalene Diimide Radical Anion with Efficient NIR-II Photothermal Conversion for E. coli-Responsive Photothermal Therapy".Angewandte Chemie - International Edition (2023).