Arteriosclerosis Assessment Based on Single-Point Fingertip Pulse Monitoring Using a Wearable Iontronic Sensor

Huang，Yi1; Zhao，Lingyu2; Cai，Minkun2; Zhu，Jiaqi2; Wang，Liu3; Chen，Xinxing4; Zeng，Yumin5; Zhang，Liqing6; Shi，Jidong7; Guo，Chuan Fei2

2023

10.1002/adhm.202301838

Advanced Healthcare Materials   Impact Factor & Quartile

2192-2640

2192-2659

Arteriosclerosis, which appears as a hardened and narrowed artery with plaque buildup, is the primary cause of various cardiovascular diseases such as stroke. Arteriosclerosis is often evaluated by clinically measuring the pulse wave velocity (PWV) using a two-point approach that requires bulky medical equipment and a skilled operator. Although wearable photoplethysmographic sensors for PWV monitoring are developed in recent years, likewise, this technique is often based on two-point measurement, and the signal can easily be interfered with by natural light. Herein, a single-point strategy is reported based on stable fingertip pulse monitoring using a flexible iontronic pressure sensor for heart-fingertip PWV (hfPWV) measurement. The iontronic sensor exhibits a high pressure-resolution on the order of 0.1 Pa over a wide linearity range, allowing the capture of characteristic peaks of fingertip pulse waves. The forward and reflected waves of the pulse are extracted and the time difference between the two waves is computed for hfPWV measurement using Hiroshi's method. Furthermore, a hfPWV-based model is established for arteriosclerosis evaluation with an accuracy comparable to that of existing clinical criteria, and the validity of the model is verified clinically. The work provides a reliable technique that can be used in wearable arteriosclerosis assessment systems.

arteriosclerosis fingertip pulses flexible pressure sensors iontronic nanointerfaces pulse wave velocity

SCI

English

First ; Corresponding

WOS:001059117100001

2-s2.0-85169337055

Scopus

1.Department of Cardiology,Southern University of Science and Technology Hospital (SUSTech-Hospital),Shenzhen,518071,China
2.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
3.CAS Key Laboratory of Mechanical Behavior and Design of Materials,Department of Modern Mechanics,University of Science and Technology of China,Hefei,230026,China
4.Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems,Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities,Southern University of Science and Technology,Shenzhen,518055,China
5.Department of Sports Center,Southern University of Science and Technology,Shenzhen,518055,China
6.Department of Endocrinology,Southern University of Science and Technology Hospital (SUSTech-hospital),Shenzhen,518071,China
7.Shenzhen Key Laboratory of Ultraintense Laser and Advanced Material Technology,Center for Advanced Material Diagnostic Technology,College of Engineering Physics,Shenzhen Technology University,Shenzhen,518118,China

Huang，Yi,Zhao，Lingyu,Cai，Minkun,et al. Arteriosclerosis Assessment Based on Single-Point Fingertip Pulse Monitoring Using a Wearable Iontronic Sensor[J]. Advanced Healthcare Materials,2023.

Huang，Yi.,Zhao，Lingyu.,Cai，Minkun.,Zhu，Jiaqi.,Wang，Liu.,...&Guo，Chuan Fei.(2023).Arteriosclerosis Assessment Based on Single-Point Fingertip Pulse Monitoring Using a Wearable Iontronic Sensor.Advanced Healthcare Materials.

Huang，Yi,et al."Arteriosclerosis Assessment Based on Single-Point Fingertip Pulse Monitoring Using a Wearable Iontronic Sensor".Advanced Healthcare Materials (2023).