Structural Morphology Changes the Fate of Semiconducting Polymers in Afterglow Luminescence Imaging
|Corresponding Author||He，Feng; Tian，Leilei|
Overcoming the highly hydrophobic and low polarity structural nature of π-conjugated polymers becomes the critical challenge for their biological applications in aqueous systems, especially for those applications that need dynamic interaction with the environment, for example, chemiluminescence, photodynamic therapy, fluorescent probe, and so on. Herein, we developed a self-assembly and morphology control strategy to enhance the afterglow luminescence of π-conjugated polymers in water. Specifically, a monodispersed afterglow π-conjugated polymer is synthesized and modified to be the macroinitiator for atom transfer radical polymerization, and consequently, a series of amphiphilic block copolymers PPV-b-POEGMA (n = 30, 45, and 60) are prepared. Unique vesicular nanostructures with uniform sizes are self-assembled from PPV-b-POEGMA polymers, and we observe that such vesicle morphology will promote afterglow luminescence leading to long-persistent and bright signals. The special vesicle morphology enables the photosensitizers to be more accessible to light and O and consequently improves the kinetics of the photochemical reactions for afterglow luminescence generation. Moreover, the vesicle morphology is also beneficial for the pharmacokinetics of in vivo applications, exhibiting a longer blood circulation time and higher tumor accumulation. In this work, the crucial role of structural morphology in determining the quality of optical bioimaging has been revealed, which deserves more attention for the design of imaging nanomaterials in the future.
First ; Corresponding
National Natural Science Foundation of China["51973089","21975115","22225504"] ; Shenzhen Fundamental Research Programs["JCYJ20220530113612027","JCYJ20210324120010028"] ; Shenzhen Science and Technology Innovation Commission[KQTD20170810111314625] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002] ; Guangdong Basic and Applied Basic Research Foundation[2020A1515110845]
|WOS Research Area|
Chemistry ; Materials Science
Chemistry, Physical ; Materials Science, Multidisciplinary
|WOS Accession No|
|ESI Research Field|
Cited Times [WOS]:0
|Document Type||Journal Article|
|Department||Department of Materials Science and Engineering|
1.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Blvd., Guangdong,518055,China
2.Guangdong Provincial Key Laboratory of Catalysis,Department of Chemistry,Shenzhen Grubbs Institute,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Blvd., Guangdong,518055,China
|First Author Affilication||Department of Materials Science and Engineering; Department of Chemistry; Shenzhen Grubbs Institute|
|Corresponding Author Affilication||Department of Chemistry; Shenzhen Grubbs Institute; Department of Materials Science and Engineering|
|First Author's First Affilication||Department of Materials Science and Engineering; Department of Chemistry; Shenzhen Grubbs Institute|
Han，Liang,Liu，Jianhua,Wei，Zixiang,et al. Structural Morphology Changes the Fate of Semiconducting Polymers in Afterglow Luminescence Imaging[J]. Chemistry of Materials,2023,35(17).
Han，Liang.,Liu，Jianhua.,Wei，Zixiang.,Gu，Ying.,Zhu，Yulin.,...&Tian，Leilei.(2023).Structural Morphology Changes the Fate of Semiconducting Polymers in Afterglow Luminescence Imaging.Chemistry of Materials,35(17).
Han，Liang,et al."Structural Morphology Changes the Fate of Semiconducting Polymers in Afterglow Luminescence Imaging".Chemistry of Materials 35.17(2023).
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