Tuning Ligands Ratio Allows for Controlling Gold Nanocluster Conformation and Activating a Nonantimicrobial Thiol Fragrance for Effective Treatment of MRSA-Induced Keratitis
|Corresponding Author||Zhou，Dejian; Jiang，Xingyu|
Bacterial keratitis is a serious ocular disease that affects millions of people worldwide each year, among which ≈25% are caused by Staphylococcus aureus. With the spread of bacterial resistance, refractory keratitis caused by methicillin-resistant S. aureus (MRSA) affects ≈120 000–190 000 people annually and is a significant cause of infectious blindness. Atomically precise gold nanoclusters (GNCs) recently emerged as promising antibacterial agents; although how the GNC structure and capping ligands control the antibacterial properties remains largely unexplored. In this study, by adjusting the ratio of a “bulky” thiol fragrance to a linear zwitterionic ligand, the GNC conformation is transformed from Au(SR) to Au(SR) species, simultaneously converting both inactive thiol ligands into potent antibacterial nanomaterials. Surprisingly, mixed-ligand capped Au(SR) GNCs exhibit superior antibacterial potency compared to their monoligand counterparts. The optimal GNC is highly potent against MRSA, showing >1024-fold lower minimum inhibitory concentration than the corresponding free ligands. Moreover, it displays excellent potency in treating MRSA-induced keratitis in mice with greatly accelerated corneal recovery (by approximately ninefold). Thus, this study establishes a feasible method to synthesize antibacterial GNCs by adjusting the ligand ratio to control GNC conformation and active non-antibacterial ligands, thereby greatly increasing the repertoires for combating multidrug-resistant bacterial infections.
NI Journal Papers ; NI论文
First ; Corresponding
National Key Ramp;D Program of China[2020YFA0908900] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003] ; Shenzhen Science and Technology Program["KQTD20190929172743294","JCYJ20200109141231365"] ; National Natural Science Foundation of China["22234004","22104050","21761142006"] ; Chinese Academy of Sciences[QYZDJ-SSW-SLH039] ; Shenzhen Bay Laboratory[SZBL2019062801004] ; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009] ; Guangdong Innovative and Entrepreneurial Research Team Program[2019ZT08Y191] ; Guangdong Major Talent Introduction Project[2019CX01Y196] ; UK Biotechnology and Biological Sciences Research Council[BB/R007829/1] ; Royal Society[IEC\NSFC\191397]
|WOS Research Area|
Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
|WOS Accession No|
|ESI Research Field|
Cited Times [WOS]:1
|Document Type||Journal Article|
|Department||Department of Biomedical Engineering|
1.Shenzhen Key Laboratory of Smart Healthcare Engineering,Guangdong Provincial Key Laboratory of Advanced Biomaterials,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No 1088, Xueyuan Rd., Nanshan District, Guangdong,518055,China
2.School of Chemistry,Astbury Centre for Structural Molecular Biology,University of Leeds,Leeds,LS2 9JT,United Kingdom
3.Institute of Antibiotics,Huashan Hospital,Fudan University,Shanghai,200040,China
4.School of Food Science and Nutrition,Astbury Centre for Structural Molecular Biology,University of Leeds,Leeds,LS2 9JT,United Kingdom
|First Author Affilication||Department of Biomedical Engineering|
|Corresponding Author Affilication||Department of Biomedical Engineering|
|First Author's First Affilication||Department of Biomedical Engineering|
Pang，Zeyang,Ren，Ning,Wu，Yujie,et al. Tuning Ligands Ratio Allows for Controlling Gold Nanocluster Conformation and Activating a Nonantimicrobial Thiol Fragrance for Effective Treatment of MRSA-Induced Keratitis[J]. Advanced Materials,2023,35(40).
Pang，Zeyang.,Ren，Ning.,Wu，Yujie.,Qi，Jie.,Hu，Fupin.,...&Jiang，Xingyu.(2023).Tuning Ligands Ratio Allows for Controlling Gold Nanocluster Conformation and Activating a Nonantimicrobial Thiol Fragrance for Effective Treatment of MRSA-Induced Keratitis.Advanced Materials,35(40).
Pang，Zeyang,et al."Tuning Ligands Ratio Allows for Controlling Gold Nanocluster Conformation and Activating a Nonantimicrobial Thiol Fragrance for Effective Treatment of MRSA-Induced Keratitis".Advanced Materials 35.40(2023).
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