Association study between C10orf90 gene polymorphisms and colorectal cancer

Song，Jian1; Wang，Kaixuan2; Chen，Zhaowei3; Zhong，Dunjing3; Li，Li4; Guo，Liangliang3; Yu，Shuyong4

2023

10.3389/fonc.2023.1192378

Frontiers in Oncology   Impact Factor & Quartile

2234-943X

2234-943X

Background: Colorectal cancer (CRC) is the third most common malignant tumor in the world. The morbidity and mortality rates in Western countries have decreased, but they are still on the rise in China. C10orf90 is associated with a variety of cancers, but the correlation between C10orf90 and CRC is not yet known. Methods: A total of 1,339 subjects were randomly enrolled in our study. After extracting their DNA, three single-nucleotide polymorphisms (SNPs) of C10orf90 were genotyped to analyze the potential relationship between these variants and CRC risk. PLINK software packages (version 1.07) were used to evaluate multiple genetic models by calculating the odds ratio (OR) and 95% confidence interval (95% CI). The best SNP–SNP interaction model was defined by the multifactor dimensionality reduction (MDR) analysis. Results: C10orf90 rs12412320 was significantly associated with CRC risk (p = 0.006) and might be associated with the lower CRC risk (OR: 0.78; 95% CI: 0.65–0.93). The relationship of rs12412320 with lower CRC risk was found in people aged >60 years and ≤60 years, women, non-smokers, or non-drinkers. Rs11245008 in people aged ≤60 years and rs11245007 among men had a higher CRC susceptibility. Rs12412320 was related to the lower risk of advanced stages (III/IV stage), while rs11245007 might be associated with the higher risk of advanced stages (III/IV stage). Moreover, rs12412320 had the most significant relationship with the susceptibility to rectal cancer. Conclusion: This study is the first to report between C10orf90 gene polymorphisms and CRC risk in Chinese people, which suggests that C10orf90 rs12412320 might play a crucial role in preventing CRC occurrence.

C10orf90 clinical features colorectal cancer demographic characteristics gene polymorphisms

SCI

English

First

Oncology

Oncology

WOS:001047486700001

FRONTIERS MEDIA SA

2-s2.0-85168112249

Scopus

1.Department of Gastroenterology,Southern University of Science and Technology Hospital,Shenzhen,Guangdong,China
2.Department of Gastroenterology,The First Affiliated Hospital of Naval Medical University,Shanghai,China
3.Department of Gastroenterology,Hainan Cancer Hospital,Haikou,Hainan,China
4.Department of Gastrointestinal Surgery,Hainan Cancer Hospital,Haikou,Hainan,China

Song，Jian,Wang，Kaixuan,Chen，Zhaowei,et al. Association study between C10orf90 gene polymorphisms and colorectal cancer[J]. Frontiers in Oncology,2023,13.

Song，Jian.,Wang，Kaixuan.,Chen，Zhaowei.,Zhong，Dunjing.,Li，Li.,...&Yu，Shuyong.(2023).Association study between C10orf90 gene polymorphisms and colorectal cancer.Frontiers in Oncology,13.

Song，Jian,et al."Association study between C10orf90 gene polymorphisms and colorectal cancer".Frontiers in Oncology 13(2023).