Design, evaluation, and immune simulation of potentially universal multi-epitope mpox vaccine candidate: focus on DNA vaccine

Rcheulishvili，Nino; Mao，Jiawei; Papukashvili，Dimitri; Feng，Shunping; Liu，Cong; Wang，Xingyun; He，Yunjiao; Wang，Peng George

2023

10.3389/fmicb.2023.1203355

Frontiers in Microbiology   Impact Factor & Quartile

1664-302X

Monkeypox (mpox) is a zoonotic infectious disease caused by the mpox virus. Mpox symptoms are similar to smallpox with less severity and lower mortality. As yet mpox virus is not characterized by as high transmissibility as some severe acute respiratory syndrome 2 (SARS-CoV-2) variants, still, it is spreading, especially among men who have sex with men (MSM). Thus, taking preventive measures, such as vaccination, is highly recommended. While the smallpox vaccine has demonstrated considerable efficacy against the mpox virus due to the antigenic similarities, the development of a universal anti-mpox vaccine remains a necessary pursuit. Recently, nucleic acid vaccines have garnered special attention owing to their numerous advantages compared to traditional vaccines. Importantly, DNA vaccines have certain advantages over mRNA vaccines. In this study, a potentially universal DNA vaccine candidate against mpox based on conserved epitopes was designed and its efficacy was evaluated via an immunoinformatics approach. The vaccine candidate demonstrated potent humoral and cellular immune responses in silico, indicating the potential efficacy in vivo and the need for further research.

DNA vaccine epidemics immunoinformatics in silico monkeypox mpox virus pandemics universal vaccine

SCI

English

First ; Corresponding

Shenzhen Science and Technology Innovation Program[KQTD20200909113758004]

Microbiology

Microbiology

WOS:001040304600001

FRONTIERS MEDIA SA

2-s2.0-85167334657

Scopus

Department of Pharmacology,School of Medicine,Southern University of Science and Technology,Shenzhen,China

Rcheulishvili，Nino,Mao，Jiawei,Papukashvili，Dimitri,et al. Design, evaluation, and immune simulation of potentially universal multi-epitope mpox vaccine candidate: focus on DNA vaccine[J]. Frontiers in Microbiology,2023,14.

Rcheulishvili，Nino.,Mao，Jiawei.,Papukashvili，Dimitri.,Feng，Shunping.,Liu，Cong.,...&Wang，Peng George.(2023).Design, evaluation, and immune simulation of potentially universal multi-epitope mpox vaccine candidate: focus on DNA vaccine.Frontiers in Microbiology,14.

Rcheulishvili，Nino,et al."Design, evaluation, and immune simulation of potentially universal multi-epitope mpox vaccine candidate: focus on DNA vaccine".Frontiers in Microbiology 14(2023).