Development of a novel 12-point grading system for evaluating epidural spinal cord compression and its clinical implications

Cao，Xuyong1,2; Jiang，Weihao2; Zhao，Xiongwei2,3; Yu，Haikuan1; Lei，Mingxing4,5; Cao，Yuncen2; Su，Xiuyun6; Liu，Yaosheng1,2,3,4

2023

10.1016/j.spinee.2023.07.019

Spine Journal   Impact Factor & Quartile

1529-9430

1878-1632

BACKGROUND CONTEXT: The assessment of epidural spinal cord compression (ESCC) plays a crucial role in clinical decision-making, yet the current grading system lacks reliability and requires improvements. PURPOSE: The study aims to develop a reliable grading system for evaluating ESCC and to investigate its association with the neurological status of patients. STUDY DESIGN/SETTING: A prospective cohort study. PATIENT SAMPLE: A total of 330 patients with metastatic spinal disease were included in the study. OUTCOME MEASURES: The main outcome was the neurological status evaluated using the American Spinal Injury Association (ASIA) scale. METHODS: We proposed a novel grading system, called the 12-point ESCC grading system, to evaluate ESCC based on findings from spinal magnetic resonance imaging (MRI). This new grading system consists of 12 grades, ranging from Grade 0 to 3, with higher grades indicating more severe ESCC. The detailed information about the sagittal image of the spine and the severity of spinal cord swelling was considered in this new grading system. The Spearman correlation analysis and logistic regression analysis were employed to investigate the correlation between the previous 6-point grading system and ASIA, as well as between the new 12-point ESCC grading system and ASIA. The prediction effectiveness was evaluated using the area under curve (AUC) analysis. RESULTS: Patients with higher grades in the 12-point ESCC grading system exhibited a higher likelihood of experiencing a worse neurological condition. Specifically, patients with grades 2a to 2d and 3a to 3d according to the new 12-point ESCC grading system were significantly associated with more complete paralysis (p<.001) compared with patients with grade 0. The Spearman correlation coefficient was 0.729 between the previous 6-point ESCC grading system and ASIS and 0.750 between the new 12-point ESCC grading system and ASIS. When categorizing ASIS into complete paralysis and other neurological statuses, the 6-point ESCC score yielded an AUC of 0.820, which increased to 0.860 with the new 12-point ESCC grading system. Furthermore, when ASIS was divided into normal and abnormal neurological statuses, the AUC increased from 0.889 to 0.906. Additionally, spinal cord swelling was significantly associated with more complete paralysis (p<.001) and abnormal neurological status (p<.001) based on the new 12-point ESCC grading system. CONCLUSIONS: The new 12-point ESCC grading system provides more detailed information and further improves the prediction effectiveness for evaluating neurological status compared with the previous 6-point ESCC grading system. In the new 12-point ESCC grading system, higher grades or the presence of spinal cord swelling are indicative of a worse neurological condition.

American spinal injury association Epidural spinal cord compression ESCC grading system Neurological status Prediction performance

English

Corresponding

2-s2.0-85166776061

Scopus

1.Department of Orthopedic Surgery,Senior Department of Orthopedics,The Fourth Medical Center of PLA General Hospital,Beijing,No. 51 Fucheng Rd, Haidian District,100048,China
2.Department of Orthopedic Surgery,The Fifth Medical Center of PLA General Hospital,Beijing,No. 8 Dongdajie Street, Fengtai District,100071,China
3.Department of Orthopedic Surgery,The Fifth Medical Center of PLA General Hospital,Fifth School of Clinical Medicine,Anhui Medical University,Hefei,No. 81 Meishan Road,230032,China
4.Department of Orthopedic Surgery,National Clinical Research Center for Orthopedics,Sports Medicine & Rehabilitation,PLA General Hospital,Beijing,No. 28 Fuxing Rd, Haidian District,100039,China
5.Department of Orthopedic Surgery,Hainan Hospital of PLA General Hospital,Sanya,No. 80 Jianglin Rd, Haitang District,572022,China
6.Intelligent Medical Innovation Institute,Southern University of Science and Technology Hospital,Shenzhen,No. 6019 Xili Liuxian Ave, Nanshan District,518071,China

Cao，Xuyong,Jiang，Weihao,Zhao，Xiongwei,et al. Development of a novel 12-point grading system for evaluating epidural spinal cord compression and its clinical implications[J]. Spine Journal,2023.

Cao，Xuyong.,Jiang，Weihao.,Zhao，Xiongwei.,Yu，Haikuan.,Lei，Mingxing.,...&Liu，Yaosheng.(2023).Development of a novel 12-point grading system for evaluating epidural spinal cord compression and its clinical implications.Spine Journal.

Cao，Xuyong,et al."Development of a novel 12-point grading system for evaluating epidural spinal cord compression and its clinical implications".Spine Journal (2023).