| Title | Antiviral activity and active components of the leaves from Sabia parviflora Wall. ex Roxb |
| Author | |
| Corresponding Author | Zhou，Ying |
| Publication Years | 2023
|
| DOI | |
| Source Title | |
| ISSN | 1478-6419
|
| EISSN | 1478-6427
|
| Abstract | Sabia parviflora (SP, “xiao hua qing feng teng” in Chinese) was recorded as an important ethnic medicine to be used for treating viral hepatitis. The antiviral activity of four SP extracts and potent antiviral compounds evaluated with cathepsin L protease (Cat L PR) and HIV-1 protease (HIV-1 PR). UPLC-HRMS was used for identifying the bioactive components. In addition, the possible inhibitory mechanism of the identified compounds on viral protease was further discussed by molecular docking. As a result, four extracts of SP exhibited inhibitory activity of HIV-1 PR and Cat L PR with IC range from 0.015 to 0.80 mg/mL. Meanwhile, six compounds inhibited HIV-1 PR with IC range from 0.032 to 0.80 mg/mL. Moreover, procyanidin B2 had good affinity for HIV-1 PR and CatL PR protein, respectively. These findings suggest S. parviflora leaves can be used for treating HIV and procyanidin B2 may play a role in antiviral protease. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Others
|
| Funding Project | Innovation Group Project of Guizhou Province[3411-4110000520364]
; Association of Natural Science of Foundation of China[SZXK059]
; Research Center of Molecular Bioactivity from Traditional Chinese Medicine and Ethnomedicine[2023A13]
; Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties[Qian Ke He Zhi cheng [2020] 4Y213]
; Bright Future Fund for Guangdong Provincial Hospital Pharmacology Research[Qian Ke He Foundation ZK [2021] General 518]
; null[Qian Jiao He KY [2021] 018]
; null[81760758]
|
| WOS Research Area | Chemistry
; Pharmacology & Pharmacy
|
| WOS Subject | Chemistry, Applied
; Chemistry, Medicinal
|
| WOS Accession No | WOS:001040680100001
|
| Publisher | |
| ESI Research Field | PHARMACOLOGY & TOXICOLOGY
|
| Scopus EID | 2-s2.0-85166767259
|
| Data Source | Scopus
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/560179 |
| Department | Department of Pharmacology 南方科技大学第一附属医院 |
| Affiliation | 1.College of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang,China 2.Department of Pharmacology,Shenzhen People’s Hospital (The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,China 3.Guizhou Bailing Group Pharmaceutical Co.,Ltd,Ansun,China 4.College of Pharmacy and Nutrition,University of Saskatchewan,Saskatoon,Canada |
| Recommended Citation GB/T 7714 |
Zhou，Yongqiang,Li，Sumei,Pan，Bowen,et al. Antiviral activity and active components of the leaves from Sabia parviflora Wall. ex Roxb[J]. Natural Product Research,2023.
|
| APA |
Zhou，Yongqiang.,Li，Sumei.,Pan，Bowen.,Xiao，Junwei.,Tang，Tingting.,...&Wei，Ying.(2023).Antiviral activity and active components of the leaves from Sabia parviflora Wall. ex Roxb.Natural Product Research.
|
| MLA |
Zhou，Yongqiang,et al."Antiviral activity and active components of the leaves from Sabia parviflora Wall. ex Roxb".Natural Product Research (2023).
|
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