Research progress of Gasdermin D Gasdermin D 蛋白的研究进展

Li，Chen Guang1,2; Mai，Feng Yi3; Liang，Jing Rong1,2; Xiao，Li Zu1,2; Zhang，Zhi Guo1

2023

10.12360/CPB202202015

Chinese Pharmacological Bulletin   Impact Factor & Quartile

1001-1978

Pyroptosis is a novel process of programmed inflammatory necrosis, which is closely related to microbial infections and autoimmune diseases. In recent years it has been proved that Gasdermin D is an executive protein of pyroptosis. Cleaved Gasdermin D leads to the formation of pores in cell membrane to induce pyroptosis, and the release of inflammatory factors such as IL-1β and IL-18 aggravates the occurrence of inflammatory responses. With the deepening of Gasdermin D research, it is gradually clear its protein structure and activation sites, which has other activation pathways apart from inducing inflammasome activation. Activation of Gasdermin D does not necessarily mean cell death, even if it could induce the formation of pores in cell membrane and regulation of inflammatory cytokine secretion. These findings offer insight into Gasdermin D function and change our understanding of pyroptosis and programmed necrosis. The recent progress of Gasdermin D is highlighted in this review.

Gasdermin D Gasdermin family inflammation inflammsome pyroptosis

Chinese

Others

2-s2.0-85165646815

Scopus

1.Shenzhen University,Health Science Center,School of Biomedical Engineering,Shenzhen,518060,China
2.Pain Management,Huazhong University of Science and Technology Union Shenzhen Hospital,Shenzhen,518052,China
3.Dept of Medicine,Southern University of Science and Technology,Shenzhen,518055,China

Li，Chen Guang,Mai，Feng Yi,Liang，Jing Rong,等. Research progress of Gasdermin D Gasdermin D 蛋白的研究进展[J]. Chinese Pharmacological Bulletin,2023,39(5):817-822.

Li，Chen Guang,Mai，Feng Yi,Liang，Jing Rong,Xiao，Li Zu,&Zhang，Zhi Guo.(2023).Research progress of Gasdermin D Gasdermin D 蛋白的研究进展.Chinese Pharmacological Bulletin,39(5),817-822.

Li，Chen Guang,et al."Research progress of Gasdermin D Gasdermin D 蛋白的研究进展".Chinese Pharmacological Bulletin 39.5(2023):817-822.