Rapid Access to Free Phenols by Photocatalytic Acceptorless Dehydrogenation of Cyclohexanones at Room Temperature
Phenols are ubiquitous substructures in natural products and bioactive compounds. However, practical methods for the direct construction of phenols under mild conditions remain challenging. Herein, a photocatalytic acceptorless hydrogen-evolution aromatization of cyclohexanones or cyclohexenones at room temperature has been developed. The reaction features the visible-light and cobalt co-catalyzed sequential dehydrogenation of in-situ formed enol silyl ethers, which are regarded as a challenging process. This operationally simple method enables the synthesis of a series of phenols with diverse substitution patterns from cyclohexanones or cyclohexenones. Moreover, diverse substituted 1,2-, 1,3-, and 1,4-benzenediols were obtained from cyclohexanediones, providing a general and straightforward method for the synthesis of phenols from simple starting materials under mild conditions.
First ; Corresponding
NSFC["21971101","22171127"] ; Guangdong Basic and Applied Basic Research Foundation[2022A1515011806] ; Department of Education of Guangdong Province[2021KTSCX106] ; Guangdong Province Graduate Education Innovation Program[2022JGXM054] ; Pearl River Talent Recruitment Program[2019QN01Y261] ; Shenzhen Science and Technology Innovation Committee[JCYJ20220519201425001] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002]
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Cited Times [WOS]:0
|Document Type||Journal Article|
|Department||Department of Chemistry|
Shenzhen Grubbs Institute,Department of Chemistry,and Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
|First Author Affilication||Department of Chemistry; Shenzhen Grubbs Institute|
|Corresponding Author Affilication||Department of Chemistry; Shenzhen Grubbs Institute|
|First Author's First Affilication||Department of Chemistry; Shenzhen Grubbs Institute|
Min，Lin,Lin，Jiani,Shu，Wei. Rapid Access to Free Phenols by Photocatalytic Acceptorless Dehydrogenation of Cyclohexanones at Room Temperature[J]. Chinese Journal of Chemistry,2023,41(21).
Min，Lin,Lin，Jiani,&Shu，Wei.(2023).Rapid Access to Free Phenols by Photocatalytic Acceptorless Dehydrogenation of Cyclohexanones at Room Temperature.Chinese Journal of Chemistry,41(21).
Min，Lin,et al."Rapid Access to Free Phenols by Photocatalytic Acceptorless Dehydrogenation of Cyclohexanones at Room Temperature".Chinese Journal of Chemistry 41.21(2023).
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