Serum Uric Acid Levels Are Associated With Macula Microvasculature Changes In Hypertensive White Matter Hyperintensity Patients
|Corresponding Author||Zhao，Yitian; Liang，Hui|
Purpose: To characterize the macula microvasculature using fractal dimension (FD) in hypertensive white matter hyperintensity (WMH) participants and explore the association between the microvascular changes and serum uric acid levels. Methods: Thirty-eight WMH participants were dementia and stroke-free, and 37 healthy controls were enrolled. Optical coherence tomographic angiography (OCTA) was used to image the superficial vascular complex (SVC), deep vascular complex (DVC), and inner vascular complex (IVC) in a 2.5-mm diameter concentric circle (excluding the foveal avascular zone FAZ). A commercial algo-rithm was used to quantify the complexity and density of the three capillary layers by fractal analy-sis. Results: WMH participants showed significantly lower FD value in the SVC (P = 0.002), DVC (P < 0.001) and IVC (P = 0.012) macula microvasculature compared with control group. After adjusting for risk factors (hypertension, diabetes, age and gender) SVC (P = 0.035) and IVC (P = 0.030) significantly correlated with serum uric acid. Conclusion: Serum uric acid levels are associated with microvascular changes in WMH. Fractal dimension based on OCTA imaging could help quantitatively characterize the macula microvascula-ture changes in WMH and may be a potential screening tool to detect serum uric acid level changes.
|WOS Research Area|
Neurosciences & Neurology
Clinical Neurology ; Neurosciences
|WOS Accession No|
|ESI Research Field|
NEUROSCIENCE & BEHAVIOR
Cited Times [WOS]:1
|Document Type||Journal Article|
|Department||Department of Computer Science and Engineering|
1.Department of Neurology,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,79 Qingchun Road,310003,China
2.Cixi Institute of Biomedical Engineering,Ningbo Institute of Materials Technology and Engineer-ing,Chinese Academy of Sciences,Ningbo,China
3.Department of Computer Science and Engineering,Southern University of Science and Technology,Shenzhen,China
Wei，Ruili,Xie，Jianyang,Meng，Fangxia,et al. Serum Uric Acid Levels Are Associated With Macula Microvasculature Changes In Hypertensive White Matter Hyperintensity Patients[J]. Current Neurovascular Research,2023,20(1):132-139.
Wei，Ruili.,Xie，Jianyang.,Meng，Fangxia.,He，Fangping.,Liu，Jiang.,...&Liang，Hui.(2023).Serum Uric Acid Levels Are Associated With Macula Microvasculature Changes In Hypertensive White Matter Hyperintensity Patients.Current Neurovascular Research,20(1),132-139.
Wei，Ruili,et al."Serum Uric Acid Levels Are Associated With Macula Microvasculature Changes In Hypertensive White Matter Hyperintensity Patients".Current Neurovascular Research 20.1(2023):132-139.
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