A Microfluidic Approach for Enrichment and Single-Cell Characterization of Circulating Tumor Cells from Peripheral Blood

Radfar，Payar1; Ding，Lin1; Es，Hamidreza Aboulkheyr1; Warkiani，Majid Ebrahimi1,2,3,4

2023

Circulating tumor cells Droplet microfluidics Enrichment Rare cell Single cell Spiral microfluidics Static droplets

English

The emergence of enabling technologies for the analysis of circulating tumor cells has been shedding new lights into cancer management in the recent years. However, majority of the technologies developed suffer from excessive cost, time-consuming workflows, and reliance on specialized equipment and operators. Herein, we propose a simple workflow for the isolation and characterization of single circulating tumor cells using microfluidic devices. The entire process can be operated by a laboratory technician without relying on any microfluidic expertise and can be completed within few hours of sample collection.

10.1007/978-1-0716-3271-0_9

Methods in Molecular Biology

2679

141-150

1064-3745

Corresponding

2-s2.0-85162083098

Scopus

1940-6029

1.School of Biomedical Engineering,University of Technology Sydney,Sydney,Australia
2.Institute for Biomedical Materials and Devices (IBMD),University of Technology Sydney,Sydney,Australia
3.SUStech-UTS Joint Research Centre for Biomedical Materials and Devices,Southern University of Science and Technology,Shenzhen,China
4.Institute of Molecular Medicine,Sechenov University,Moscow,Russian Federation

Radfar，Payar,Ding，Lin,Es，Hamidreza Aboulkheyr,et al. A Microfluidic Approach for Enrichment and Single-Cell Characterization of Circulating Tumor Cells from Peripheral Blood. 2023-01-01.